Pharmaceutical Biotechnology: Drug Discovery and Clinical ApplicationsOliver Kayser, Heribert Warzecha This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also the use of biopharmaceuticals in diagnostics and vaccinations. With a foreword by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at MIT and member of the National Academy of Engineering and the National Academy of Sciences. |
Contents
3 | |
15 | |
Mammalian Cells in Biotech Production | 43 |
Biopharmaceuticals from Plants | 59 |
Production of Biopharmaceuticals in Transgenic Animals | 71 |
Shaping | 113 |
Part Two Bringing the Drug into Action From Downstreaming | 153 |
Downstream Processing | 179 |
Pharmacokinetics and Pharmacodynamics of Therapeutic Peptides | 337 |
Scientific Technical and Economic Aspects of Vaccine Research | 371 |
New Nanobiotechnological Strategies for the Development of Vectors | 391 |
Development Production and Application | 423 |
Presentation | 440 |
In Silico and UltrahighThroughput Screenings uHTS in Drug | 453 |
Metabolic Engineering of Medicinal Plants and Microorganisms for | 491 |
Metabolomics as a Bioanalytical Tool for Characterization of Medicinal | 527 |
Characterization of Recombinant Proteins | 201 |
IO Formulation Strategies for Recombinant Protein and Related | 235 |
Drug Approval in the European Union and United States | 257 |
Legal | 269 |
Biosimilar Drugs | 285 |
Other editions - View all
Common terms and phrases
activity adjuvant amino acid analysis analytical animals antigen application approach approved artemisinin assays benefits bioactive biological biomarkers biopharmaceuticals bioreactors biosimilar Biotechnol biotechnology cancer cell culture cell lines cellular chemical chromatography clinical trials coli complex compounds defined disease DNA microarrays drug discovery effects efficacy efficient enzyme example expression factor field final first formulation functional gene genetic genome glycosylation hormone human identification immune response immunogenicity influence influenza insulin interactions ligand mammalian medicinal plants metabolites metabolomics methods microarrays modification molecular molecules monoclonal antibodies nanoparticles nutraceuticals ofthe particles patent pathway PEGylated peptide personalized medicine Pharm pharmaceutical pharmacokinetic phase PLGA potential profiling protein drugs proteomics purification receptor recombinant protein regulatory sample scientific screening sequence significant specific stability stem cells studies synthetic biology target techniques testing therapeutic proteins therapy tion tissue toxicity Toxicogenomics transgenic tumor vaccine vectors virosomes virus vitro vivo xenotransplantation