Advances in Behavioral Biology, Volume 34Plenum Press, 1971 - Biology |
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Page 53
UBIQUITIN IN ALZHEIMER AND OTHER NEURODEGENERATIVE DISEASES George Perry , Valeria Manetto , and Paul Mulvihill Division of Neuropathology , Institute of Pathology , Case Western Reserve University , Cleveland , Ohio 44106 INTRODUCTION ...
UBIQUITIN IN ALZHEIMER AND OTHER NEURODEGENERATIVE DISEASES George Perry , Valeria Manetto , and Paul Mulvihill Division of Neuropathology , Institute of Pathology , Case Western Reserve University , Cleveland , Ohio 44106 INTRODUCTION ...
Page 54
Presence of Ubiquitin in Alzheimer NFT Using affinity purified antibodies to ubiquitin , Mori et al ( 1 ) and Perry et al ( 2 ) demonstrated ubiquitin in NFT , in neurites surrounding senile plaques and in altered neurites in the ...
Presence of Ubiquitin in Alzheimer NFT Using affinity purified antibodies to ubiquitin , Mori et al ( 1 ) and Perry et al ( 2 ) demonstrated ubiquitin in NFT , in neurites surrounding senile plaques and in altered neurites in the ...
Page 58
... ubiquitin dependent proteolysis of NFH and tau , as well as possibly unidentified neuritic components ( 16 ) , would provide the building blocks for new polymers . The presence of ubiquitin within the altered neurites of Alzheimer ...
... ubiquitin dependent proteolysis of NFH and tau , as well as possibly unidentified neuritic components ( 16 ) , would provide the building blocks for new polymers . The presence of ubiquitin within the altered neurites of Alzheimer ...
Contents
A Review and Update | 1 |
The Phosphorylation of the Microtubuleassociated | 25 |
Human Amyloidosis and In Vitro Formation of Alzheimer Amyloid | 33 |
Copyright | |
16 other sections not shown
Common terms and phrases
Acad Sci USA Acta Neuropathol Berl actin actin filaments AD/SDAT alpha-actinin Alzheimer disease Alzheimer neurofibrillary tangles Alzheimer paired helical Alzheimer's disease amyloid fibrils amyloidosis antisera Autilio-Gambetti axonal transport bind Biochem Brain Res cDNA Cell Biol characterized contain cytoplasmic cytoskeletal electron microscopic epitopes et.al formation Gambetti Grundke-Iqbal hippocampus Hirano bodies Ihara Immunocytochemical studies immunoreactivity immunostained inclusions insoluble intermediate filaments Iqbal isolated Kosik KS Lewy bodies MAP2 MAPS micrographs microtubule assembly microtubule-associated protein molecular weight monoclonal antibodies Natl Acad Sci neurites neurofibrillary tangles neurofilament proteins neuronal cytoskeleton Neuropathol Exp Neurol Neurosci NF-H NF-L NF-M normal paired helical filaments Parkinson's disease Pathol perikarya Perry G PHF polypeptides phosphorylation Pick bodies Pick's disease plaque cores polyclonal Proc Natl Acad protofilaments Scale bar Selkoe DJ senile plaque sequence share antigenic determinants staining Sternberger structure subunit tau protein tropomyosin tubulin ubiquitin ultrastructural vinculin vitro Wisniewski Yen S-H