The Parvoviruses, Page 3; Page 276
The Parvoviridae have been of increasing interest to reseachers in the past decade. Their small size and simple structure have made them ame nable to detailed physiochemical analysis, and from this work relatively detailed information has resulted that has signficantly increased our un derstanding of the biology of these viruses. It has become clear that the Parvoviridae are of interest not only for their own sake, but also because their relative simplicity renders them useful probes in the study of the biology of host cells and of other DNA viruses with which they interact. The Dependovirus genus, for instance, contains the defective adeno-as sociated viruses (AA V), which require a coinfection with either an ad enovirus or a herpesvirus for productive multiplication. Studies of AA V, therefore, necessarily impinge on our understanding of the control of macromolecular synthesis by the helper virus. Similarly AA V has been reported to inhibit the oncogenicity of both adeno-and herpesviruses and has been used as a probe of mechanism in these instances as well. Finally, AA V establishes latent infections in vivo and is the only mammalian DNA virus where a comparable model system has been established in cell culture. This system has allowed study of the mechanism of latent infection at the molecular level.
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A Model for AAV DNA Replication
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AAV capsid proteins AAV DNA AAV DNA replication AAV genome AAV growth AAV helper function AAV proteins AAV RNA synthesis AAV2 Acad Ad5ts adeno-associated virus adenovirus DNA adenovirus early genes adenovirus genes adenovirus type adenovirus-associated virus Aleutian disease analysis antibody antigen appears autonomous parvovirus Berk and Sharp Berns Biol canine canine parvovirus capsid cellular coinfection Cold Spring Harbor contain cytoplasmic defective deletion disease DNA polymerase DNA replication DNA synthesis duplex eukaryotic evidence feline panleukopenia virus fragments genome hairpin hamsters Handa help AAV Hoggan host hybrid infected cells inhibition isolated KB cells Kilham Laughlin LuIII map position mink minute virus mRNA mutants Natl nucleotide observed palindromic particles polypeptides Proc progeny promoter RF DNA Rhode Siegl single-stranded specific splicing SS DNA structure studies suggested Tattersall terminal sequence Toolan variant DNA Vero cells viral DNA viral strand virion Virol Virology viruses vitro vivo Ward