Therapy of Crohn's Disease, Volume 71
Karger Medical and Scientific Publishers, Jan 1, 2005 - Medical - 62 pages
The management of Crohn's disease is still a challenge due to the complexity of therapeutical decision-making, which has recently become even more difficult because of novel biological therapies. Thus, criteria to assess the appropriateness of therapeutical options are called for. One well-accepted method is the RAND Appropriateness Method, integrating a systematic review of the medical literature with personal experience of experts in the field. The so found appropriateness criteria may then serve as a basis for guidelines concerning therapy and to assist individual clinicians in their treatment choices. Aiming to apply the RAND Appropriateness Method approach to the treatment of Crohn's disease, the European Panel on the Appropriateness of Crohn's Disease Therapy has been organized under the auspices of the European Crohn's and Colitis Organisation. The publication at hand presents the literature reviews produced for the purpose of the panel, whose 15 experts have evaluated them in depth. They focus, among other things, on drug safety, severe and steroid resistant Crohn's disease, extra intestinal manifestation of Crohn's disease, maintenance of remission or pregnancy and Crohn's disease. Discussing a multitude of issues connected with Crohn's disease, this publication offers the practicing physician a wealth of information for his daily work.
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34 E-Mail firstname.lastname@example.org 6-mercaptopurine active Crohn’s disease adverse events Aliment Pharmacol Ther antibiotics azathioprine Basel Basle beneﬁt budesonide CDAI chronic active Crohn’s ciproﬂoxacin Clin clinical colonic controlled trial Cooperative Crohn’s Disease corticosteroids Crohn’s Disease Study cyclosporine deﬁned Digestion disease activity Division of Gastroenterology dose double-blind drugs ease efﬁcacy endoscopic Engl extraintestinal manifestations ﬁrst ﬁstulas Gastro gastroduodenal Gastroenterol Gastroenterology Gastroenterology and Hepatology gastrointestinal immunosuppressive induce remission inﬂammatory bowel disease inﬂiximab infusion intestinal intravenous Karger Lausanne University Lausanne University Medical long-term maintaining remission ment mesalamine meta-analysis methotrexate metronidazole mg/day mg/kg mild to moderate months mycophenolate mofetil natalizumab obstructive oral patients with Crohn’s Pentasa perianal Pierre Michettia placebo placebo group postoperative prednisone pregnancy Pregnancy Category pyoderma gangrenosum randomized recurrence refractory resection risk severe disease signiﬁcant speciﬁc steroids strictures Study Group sulfasalazine surgery surgical symptoms tacrolimus tients tion treated treatment of Crohn’s ulcerative colitis University Medical Center uveitis weeks