Human Developmental Toxicants: Aspects of Toxicology and Chemistry
Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities for 50 known agents that adversely affect prenatal and postnatal human development in terms of growth, viability, structure, and function.
This book presents data linking chemical and structural properties of specific toxicants as they relate to toxic effects, dosage, timing, and route of exposure. Focusing on one compound per chapter, the book also includes associated biological data from animals for each agent covered. An accompanying CD summarizes all of the data discussed in the text within an electronic database. In addition, the CD contains three-dimensional structure representations and 49 calculated physicochemical and topological parameters of the selected molecules. This information is useful for building structure activity relationship (SAR) models linking the chemical properties with observed human developmental toxicity.
As scientists continue to explore how chemicals alter human development, Human Developmental Toxicants contains the necessary information to further identify which chemical properties are responsible for adverse effects. This reference provides toxicologists, teratologists, chemists and other scientists with the latest data and information needed to perform risk assessments, predict chemicals that may produce developmental toxicity, and regulate harmful exposure.
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abnormalities anomalies anticonvulsant antiepileptic drugs associated Birth Defects birth weight bond acceptor bond donor caffeine calculated physicochemical carbamazepine Clin cocaine congenital malformations debye Topological Properties DEVELOPMENTAL TOXICOLOGY Animals diethylstilbestrol doses embryopathy etretinate exposed female fetal alcohol syndrome fetus Friedman and Polifka g/mol Genet gestation Gynecol H bond Human developmental toxicants Human functional deficit Human growth retardation Human malformation Hydrogen bonding hydrophilic Hydrophilic surface area infants intrauterine isotretinoin J. M. and Polifka Lancet limb LogP LUMO maternal methimazole mg/kg/day mice misoprostol Molecular volume Multiple Neonatal Obstet offspring oral outcome Parameter Value Molecular Pediatr Percent hydrophilic surface phenytoin physicochemical and topological Physicochemical Properties Parameter Polar surface area prenatal Properties Parameter Value rabbits rats reported Reprod Schardein Solubility parameter spontaneous abortion teratogenesis teratogenic Teratogenic Effects teratogenic risk Teratology thalidomide therapeutic therapy Topological Properties Unitless Toxicol treatment tretinoin trimester utero valproate valproic acid vitamin warfarin women xvp3 xvp4 xvp5 xvp6 xvp7 xvp8 xvp9