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abortions Abstracts of Selected acid acrocentrics anencephaly anomalies assay atresia autosomal Barr bodies bilateral biochemical BIRTH DEFECTS blood born cells child chromo cleft palate Clin clinical confirmed CONGENITAL MALFORMATIONS deformities Dept discussed disease dominant dose Down's syndrome drug effect embryos evidence factors female fetal fetuses frequency gene genetic gestation heritable heterozygotes Hosp hydrocephalus incidence increased infants infection inheritance Inst involved karyotype literature litter male MARCH OF DIMES maternal age mechanism meclizine medication mental retardation metabolic mice minute reel mongolism mongoloid months mosaicism mothers multiple mutation NATIONAL FOUNDATION neonatal newborns NF-MOD nondisjunction normal offspring pairs parents patients patterns Pediat pedigree phenotypic phenylalanine phenylketonuria phocomelia population pregnancy presented proband protein recessive references reported resorption Selected Articles serum sex chromatin sex chromosome showed sibs significant studies suggests synthesis teratogenic thalidomide tion tissue translocation twins types Univ