Handbook of the Aging BrainEugenia Wang, D. Stephen Snyder Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapters discuss the affect of aging on learning and memory, language, and cognition. |
Contents
| 1 | |
CHAPTER 2 STRESS GLUCOCORTICOIDS AND HIPPOCAMPAL AGING IN RAT AND HUMAN | 19 |
CHAPTER 3 SPATIAL COGNITION AND FUNCTIONAL ALTERATIONS OF AGED RAT HIPPOCAMPUS | 51 |
THE IMPACT OF GENE TARGETING | 67 |
CHAPTER 5 NORMAL AGING AND ALZHEIMERS DISEASE | 83 |
CHAPTER 6 TRANSGENIC MOUSE MODELS WITH NEUROFILAMENTINDUCED PATHOLOGIES | 93 |
CHAPTER 7 TRANSGENIC MODELS OF AMYOTROPHIC LATERAL SCLEROSIS AND ALZHEIMERS DISEASE | 107 |
CHAPTER 8 TOWARD A GENETIC ANALYSIS OF UNUSUALLY SUCCESSFUL NEURAL AGING | 125 |
ROLE OF THE LEWY BODY | 143 |
BIOCHEMICAL MODIFICATIONS DEGRADATION AND ALZHEIMERS | 153 |
CHAPTER 12 A NOVEL GENE IN THE ARMADILLO FAMILY INTERACTS WITH PRESENILIN 1 | 171 |
CHAPTER 13 PUTATIVE LINKS BETWEEN SOME OF THE KEY PATHOLOGICAL FEATURES OF THE ALZHEIMERS BRAIN | 181 |
CHAPTER 14 UNRAVELING THE CONTROVERSY OF HUMAN PRION PROTEIN DISEASES | 201 |
CHAPTER 15 TRANSLATIONAL CONTROL APOPTOSIS AND THE AGING BRAIN | 223 |
CHAPTER 16 ASTROCYTE SENESCENCE AND THE PATHOGENESIS OF PARKINSONS DISEASE | 243 |
| 259 | |
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A-type K+ abnormal Acad age-related aged rats Alzheimer Alzheimer's disease amino acid amyloid amyotrophic lateral sclerosis ApoE4 apolipoprotein apoptosis Aẞ peptides astrocytes axonal basal binding Biochem Biol Brain Res calpain cellular Chem cholinergic clinical cognitive control subjects cortex cortical corticosterone cortisol cortisol levels Creutzfeldt-Jakob disease cytoskeletal decrease deficits degeneration dementia domain effects familial function genetic glycation hippocampal human impaired increased interaction intracellular kinase learning lesions Lewy bodies mechanisms memory molecular monkeys motor neurons mouse mRNA mutations Natl Neurobiol neurofibrillary tangles neurofilament Neurology neuronal loss Neuropathol Neurosci NF-H NF-L normal old rats oxidative Parkinson's disease pathology pathway patients peptides phenotype PHF-tau phosphorylation place cells place field plaques plasma potentiation presenilin prion protein prion protein diseases Proc Prusiner receptor regions role scrapie signal Sisodia SOD1 spatial stress studies subunit superoxide synaptic tion tissues transgenic transgenic mice vitro