New Research on DNA Repair

Front Cover
Nova Publishers, 2007 - Science - 393 pages
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As a major defence against environmental damage to cells DNA repair is present in all organisms including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. DNA repair is involved in processes that minimise cell killing, mutations, replication errors, persistence of DNA damage and genomic instability. Abnormalities in these processes have been implicated in cancer and ageing. This book presents leading-edge research from around the world in this frontal field.
 

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Contents

Molecular Targeting of DNA Repair A Means to Improve Therapeutic Index Spencer J Collis
1
DNA Repair and Lung Cancer Chikako Kiyohara1 Koichi Takayama2 and Yoichi Nakanishi2
39
Comet Assay as a Tool to Evaluate DNA Repair Activity and Inhibition Dellia Cavallo and Cinzia Lucia Ursini
85
Dietary Compounds that Enhance DNA Repair and their Relevance to Cancer and Aging Harris Bernstein13 Cheray CrowleySkillicorn1 Carol Bernst...
99
Gene Prophylaxis of Endogenous DNA Damage Guido Frosina
115
Translesion DNA SynthesisA Fundamental DNA Damage Tolerance Mechanism Errol C Friedberg and Lisa D McDaniel
167
LongTerm RNA Interference Toward a Set of Isogeneic Human Cells Deficient in DNA Repair Genes DSF Biard and JF Angulo
191
Peculiarities of Base Excision Repair in Loach Embryogenesis Natalia Sharova
219
Roles of Plant Transcription Factor IIH subunit homologs in nucleotide Excision Repair and Transcription Desina M Grice1 Megan J Osmond Micha...
251
Repair of RadiationInduced DNA DoubleStrand Breaks in Human Cells History Progress and Controversies Aurellie Joubert12 and Nicolas Foray1
273
DNA DoubleStrand Breaks Repair Pathways in the Framework of Chromatin Tom C Karagiannis12 and Assam ElOsta3
295
Role of p53 in the Repair of Ionizing RadiationInduced DNA Damage David Murray and Razmik Mirzayans
325
Index
375
Copyright

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Page 363 - KASTAN, MB, ZHAN, Q., EL-DEIRY, WS, CARRIER, F., JACKS, T., WALSH, WV, PLUNKETT, BS, VOGELSTEIN, B. and FORNACE. AJ, JR. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia.
Page 363 - Participation of p53 protein in the cellular response to DNA damage.
Page 26 - Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells.

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