New Research on DNA Repair
As a major defence against environmental damage to cells DNA repair is present in all organisms including bacteria, yeast, drosophila, fish, amphibians, rodents and humans. DNA repair is involved in processes that minimise cell killing, mutations, replication errors, persistence of DNA damage and genomic instability. Abnormalities in these processes have been implicated in cancer and ageing. This book presents leading-edge research from around the world in this frontal field.
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DNA Repair and Lung Cancer Chikako Kiyohara1 Koichi Takayama2 and Yoichi Nakanishi2
Comet Assay as a Tool to Evaluate DNA Repair Activity and Inhibition Dellia Cavallo and Cinzia Lucia Ursini
Dietary Compounds that Enhance DNA Repair and their Relevance to Cancer and Aging Harris Bernstein13 Cheray CrowleySkillicorn1 Carol Bernst...
Gene Prophylaxis of Endogenous DNA Damage Guido Frosina
Translesion DNA SynthesisA Fundamental DNA Damage Tolerance Mechanism Errol C Friedberg and Lisa D McDaniel
LongTerm RNA Interference Toward a Set of Isogeneic Human Cells Deficient in DNA Repair Genes DSF Biard and JF Angulo
Peculiarities of Base Excision Repair in Loach Embryogenesis Natalia Sharova
Roles of Plant Transcription Factor IIH subunit homologs in nucleotide Excision Repair and Transcription Desina M Grice1 Megan J Osmond Micha...
Repair of RadiationInduced DNA DoubleStrand Breaks in Human Cells History Progress and Controversies Aurellie Joubert12 and Nicolas Foray1
DNA DoubleStrand Breaks Repair Pathways in the Framework of Chromatin Tom C Karagiannis12 and Assam ElOsta3
Role of p53 in the Repair of Ionizing RadiationInduced DNA Damage David Murray and Razmik Mirzayans
activity adducts agents alkylating antisense associated AtTFBIA base excision repair binding Biol Chem Cancer Res carcinogenesis Caucasian cell cycle cell lines cellular checkpoint chromatin chromosome comet assay complex defective DNA damage DNA double-strand breaks DNA glycosylase DNA ligase DNA polymerase DNA repair genes DNA-PKCS doses DSB repair effects end-joining endogenous endonuclease enzyme eukaryotes exposure expression factors fibroblasts function gene therapy genetic genome genotype histone homologous HR-repair human cells increased induced inhibition interaction involved ionizing radiation kinase loach lung cancer lung cancer risk mammalian cells mice Mol Cell Biol molecular mRNA mutagenesis mutations Natl Acad Sci NHEJ nucleotide excision repair overexpression oxidative DNA damage PARP PCNA phenotype phosphorylation plasmid polymorphism radiosensitivity recombination repair pathway repair proteins response risk of lung role sensitivity sequence siRNA specific strand breaks studies substrates synthesis target TFIIH transcription transfection transgene tumor vectors vitro vivo XRCC1 yeast
Page 363 - KASTAN, MB, ZHAN, Q., EL-DEIRY, WS, CARRIER, F., JACKS, T., WALSH, WV, PLUNKETT, BS, VOGELSTEIN, B. and FORNACE. AJ, JR. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia.