Immunology of Rheumatic DiseasesSudhir Gupta, Norman Talal Recent developments in basic science and clinical rheumatology make it appropriate at this time to create a volume devoted to the immunology of rheumatic diseases. The impact of molecular biology, gene cloning, and new technologies for establishing hybridomas and T-cell lines in the laboratory is now beginning to be felt in clinical medicine. There is a general air of excitement and a feeling that we stand on the threshold of a new era in molecular medicine and clinical science. It is this excitement that we have tried to capture in this book. This volume is divided into five sections entitled Basic Mechanisms, Autoimmunity, Classical Concepts of Rheumatic Diseases, Pathogenetic Mechanisms, and Therapy. This is not an arbitrary arrangement but represents our belief that from an understanding of basic mechanisms of disease pathogenesis will come new and more successful forms of treatment for the sufferers of rheumatic disorders. We have tried in the selection of authors to choose internationally recognized experts who have both a scientific and a clinical orientation to their subjects. We believe the marriage of clinical and basic disciplines represents the best hope for rapid knowledge transfer from the laboratory to the clinic, where such knowledge can be used to improve patient health. |
Contents
Human Immune Response Genes | 3 |
Phenotypic Expression and Functions | 21 |
The Autologous Mixed Lymphocyte Reaction | 35 |
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abnormalities allogeneic AMLR anticoagulant antigen Arthritis Rheum assay associated autoantibodies autoimmune autologous binding cellular chemotactic chronic circulating Clin clinical collagen complement connective tissue cytotoxic decreased defect deficiency demonstrated dendritic cells drug effects enzyme fibroblasts function gene gout Gupta Hageman factor human hyperuricemia immune complexes immune response immunoglobulin Immunol immunologic immunoregulatory increased induced infection inflammatory inhibition interactions interferon Interleukin Invest joint kallikrein leukocyte levamisole levels lupus anticoagulant lymphocytes lymphoid macrophages mechanisms membrane mice molecular molecules monoclonal antibodies monocytes mononuclear cells neutrophils non-T normal observed pathogenesis patients with rheumatoid peripheral blood plasma plasmapheresis platelet Proc production proliferation protein rats reactivity renal reported Rheum rheumatic diseases rheumatic fever rheumatoid arthritis rheumatoid factor Rheumatol role scleroderma sera serum SLE patients specific stimulation streptococcal studies subpopulations subsets suppressor cell syndrome synovial fluid synthesis systemic lupus erythematosus T-cell therapy thymic treatment urate uric acid vasculitis vitro vivo