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E P Abraham and G G F Newton
T F Emery
T F Emery 439
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14C-labeled acetate acetylenic Acta actino actinomycin addition amino acids analogue antibiotic antibiotic produced antibiotic synthesis antibioticus aspergillic aspergillic acid Bacillus bacitracin Bacteriol Biochem biogenesis Biol Biophys biosynthesis Birch Bohlmann brevis Brockmann Bu'Lock carbon atoms carboxyl cell cell-free cephalosporin chain Chem chemical chloramphenicol compounds cultures d-glucose degradation derived edeine enzyme erythromycin experiments extract fermentation formation formed glucose glycine gramicidin griseofulvin griseus growth hadacidin hydrolysis hydroxyproline ic/mmole ig/ml incorporation incubation inhibition inhibitors intermediate isolated isotope Katz l-valine labeled lactone lincomycin macrolide mechanism medium metabolism metabolites methionine methyl group Microbiol mitomycin moiety molecule mutants mycelium mycin mycobacillin neomycin neosamine nitrogen novobiocin obtained organism oxidation pathway penicillin peptide phenoxazinone phosphate pigment polyacetylenes polymyxa polymyxin precursor present prodigiosin production proline propionate protein synthesis pyocyanine pyrrolnitrin radioactivity reaction reported ring sarcosine shikimic specific activity strain streptidine streptomycin structure studies substrate suggested Table tetracycline tyrocidine variotin Waksman yield