Pharmacogenetics of drug metabolism
This volume features thorough reviews by active clinicians and researchers of drug metabolizing reactions which show genetic variability between humans. This includes the molecular and biochemical aspects of key enzymes and the pharmacological consequences. Also included are selected epidemiological and methodological topics intended to be of use to researchers pursuing further investigation in this field.
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OVERVIEW OF PHARMACOGENETICS
GENETIC VARIANTS OF HUMAN SERUM
PURIFICATION AND CHARACTERIZATION OF HEPATIC
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acetaldehyde acetylator phenotype Agarwal alcohol dehydrogenase aldehyde dehydrogenase ALDH ALDH2 ALDH2 isozyme allele amines amino acid arylesterase activity assay atypical BChE bilirubin Biochem Biol Biophys blood Burchell cancer catalase catalyzed cDNA cells Chem cholinesterase chromosome Clin clinical clones compounds concentrations conjugation correlation deficiency disease dose drug metabolism effects enzyme enzyme activity erythrocyte esterase ethanol Evans excretion frequency gene genetic polymorphism genotype glucuronidation Goedde GST1 Harada hepatic human liver human serum hydralazine hydrolysis hydrolyzed inactivation individuals inheritance inhibition isoenzymes isoniazid isozymes Kalow levels liver microsomes Lockridge locus MAO-A MAO-B metabolites mitochondrial molecular monoamine oxidase normal oxidation paraoxon paraoxonase activity patients Pharmac Pharmacogenetics phenol plasma platelet population procainamide protein PST activity purified rapid acetylators rat liver samples sequence slow acetylators studies substrate specificity subunits succinylcholine sulfamethazine sulfate syndrome thermal stability tissues toxicity TPMT trimethylamine trimethylaminuria UDP-glucuronosyltransferase UDPGT activity urine variation Weinshilboum xenobiotics