Pharmacogenetics of Drug Metabolism
This volume features thorough reviews by active clinicians and researchers of drug metabolizing reactions which show genetic variability between humans. This includes the molecular and biochemical aspects of key enzymes and the pharmacological consequences. Also included are selected epidemiological and methodological topics intended to be of use to researchers pursuing further investigation in this field.
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OVERVIEW OF PHARMACOGENETICS
GENETIC VARIANTS OF HUMAN SERUM
PURIFICATION AND CHARACTERIZATION OF HEPATIC
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Acad acetylator acetylator phenotype Ah receptor aldehyde dehydrogenase ALDH ALDH2 allele amino acid amino acid sequence antibodies arylesterase atypical BChE bilirubin Biochem Biochemistry Biol Biophys BURCHEll cancer catalase catalytic activity cDNA cells characterization Chem cholinesterase chromosome Clin cloning compounds cytochrome P-450 cytochrome P-450 isozymes debrisoquine deficiency dose drug metabolism enzyme enzyme activity esterase ethanol excretion gene glucuronidation Goedde Gonzalez GUENGERICH hepatic hepatic microsomal human liver human serum hydroxylase hydroxylation increase induced inhibition isoenzymes isolated isoniazid isozymes Kalow levels liver liver cytochrome P-450 MAO-A MAO-B metabolites mice microsomal cytochrome P-450 microsomes mitochondrial molecular monoamine oxidase mouse mRNA Natl NEBERT oxidation P-450 induction paraoxon patients Pharmac pharmacogenetic phenobarbital phenol phenotype plasma platelet Proc protein PST activity purified rabbit rapid acetylators rat liver microsomes regulation Ryan samples slow acetylators steroid structure studies subunit sulfate testosterone tissues toxicity trimethylamine UDP-glucuronosyltransferase UDPGT activity urine variation Weinshilboum xenobiotic