Three-dimensional Radiation Treatment: Technological Innovations and Clinical Results
H. J. Feldmann, P. Kneschaurek, Michael Molls
Karger Medical and Scientific Publishers, Jan 1, 2000 - Medical - 191 pages
Radiation therapy is in the process of continual change, fueled by advances in computer technology, but also aided by the contributions of several disciplines such as physics, mathematics, radiological diagnostics, neurosurgery, and mechanical and electrical engineering. Based on the 3D imaging techniques CT and MRI, a complete change from the 2D consideration of the radiotherapy problem has taken place, leading to 3D treatment planning and to completely new treatment delivery systems. A 3D approach allows for a dramatic rethinking of the following central therapy issues: positioning, targeting, and dose and risk calculation. Major advances have been made in recent years in conformal or stereotactic techniques, in dosimetry, the target volume concept as well as clinical studies. The advances are reflected in the papers collected here from the international symposium '3D Radiation Treatment: Technological Innovations and Clinical Results' held in Munich in March 1999. The reports present the newest technical developments and clinical applications. New conformal and stereotactic technologies are discussed. Clinical results are presented in the treatment of lung cancer, prostate cancer, and brain tumors. The role of growth factors and cytokines in the pathogenesis of radiation injury is examined as are mechanisms in the development of normal tissue damage and their significance for understanding tolerated radiation dose. Included are reports on endovascular brachytherapy and new tools of 3D brachytherapy. This timely book will be of particular interest to radiation oncologists and related clinical practitioners, biologists and physicists.
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adjuvant adjuvant RT astrocytoma beam beneﬁt brachytherapy brain metastases catheters chemotherapy Clin Oncol Clinical Results compared conformal radiotherapy deﬁned deﬁnition diﬀerent disease dose distributions dose escalation dosimetry EGFR evaluation Feldmann HJ ﬁelds ﬁg ﬁrst follow-up fractionation Front Radiat Ther glioblastoma glioblastoma multiforme grade growth factor hyperfractionated imaging implant IMRT IMT-SPECT inﬂuence Innovations and Clinical Int J Radiat inverse planning irradiation Kneschaurek locally advanced lung cancer lymph node malignant margins median meningiomas Molls M eds multivariate analysis neoadjuvant non-small-cell lung cancer NSCLC Oncol Biol Phys overall survival photon prognostic factor prostate cancer proton Radiat Oncol Biol Radiat Ther Oncol radiation dose radiation therapy radical prostatectomy radiochemotherapy Radiother randomized trial rectal bleeding rectal wall rectum recurrence resection RTOG seminal vesicles side eﬀects signiﬁcant signiﬁcantly source dwell positions speciﬁc target volume techniques Three-Dimensional Radiation Treatment total dose treatment planning tumor volume univariate Urol