Annual Reports in Combinatorial Chemistry & Molecular Diversity 2, Volume 2
M.R. Pavia, W.H. Moos
Springer, Jun 30, 1999 - Science - 180 pages
Combinatorial chemistry and molecular diversity approaches to scientific and novel product R & D have exploded in the 1990s. For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. The second volume in this series includes contributions on methods, solid phases, purification, analysis, carbohydrates, patent strategies and tactics, diversity profiling and combinatorial series design, and finishes with a survey of chemical libraries yielding biologically active agents and a compendium of solid phase chemistry publications. Each contribution is prepared by a recognized expert resulting in a high quality account of the recent advances in the field.
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Recent advances in solid phase synthesis
Analytical methods for quality control of combinatorial libraries
Patent strategies in molecular diversity
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agonist Agrafiotis aldehyde algorithm Alkylation alkyne amide amino acids analysis Angew antagonists Application approach aryl assay atoms automated bead Bioorg bond brary carboxylic acid Catalysts Chem chemical libraries chloride cleavage clustering combinatorial chemistry Combinatorial Synthesis complex compounds Comput construction Derivatives described descriptors developed drug discovery Ellman encoded Engl Enzyme Esters exemption FDA approval FDA regulatable product Figure fluorous Frechet glycosylation heterocyclic hexapeptide Houghten HPLC infringement inhibitors integrin Leznoff ligands Linker Meldal methods mixture molecular diversity molecules N-substituted glycine NeoRX nM Library novel obtain FDA oligosaccharide Organic Synthesis parallel synthesis patented invention pharmacophore phosphine Polymer Polymer Supports Polymer-Bound Polymer-Supported Polymeric polystyrene prepared properties protease protecting groups protein purification reaction reagents receptor reported resin bound screening selection solid phase organic Solid Phase Synthesis Solid Support solution strategy structure Synthe targets techniques TentaGel Tetrahedron Lett therapeutic tion trisaccharide ureas Wang