Molecular, Cellular, and Clinical Aspects of AngiogenesisMichael E. Maragoudakis There has been an explosion of research activity related to angiogenesis in recent years, and hundreds of laboratories worldwide are actively involved in many aspects of angiogenesiS. The literature on angiogenesis increases exponentially every year, and more than 16,000 peer-reviewed articles have been published the past 25 years, which are scattered in basic science and clinical journals. The complexity of the cascade of events leading to new vessel formation from preexisting ones has challenged scientists in cell biology, biochemistry, physiology, pharmacology, molecular biology, developmental biology, and other fields. With their multidisciplinary approach and the powerful new techniques that have been developed, the progress in understanding angiogenesis has been impressive indeed. Only 12 years ago the mention of an angiogenic factor caused skepticism. Today we have the complete amino-acid fiequence and their genes cloned for at least 9 angiogenic factors. Many laboratories are studying their role in angiogenesis, and several biotechnology firms have a keen interest in commercial developments relative to these molecules. The role of extracellular matrix components in angiogenesis and the interaction of endothelial cells with other cell types such as pericytes, smooth muscle cells, and inflammatory cells have been studied by other groups. This rapid expansion is the result of a realization that in many disease states a common underlying pathology is a derangement in angiogenesis. |
Contents
| 1 | |
Gene expression and endothelial cell differentiation | 19 |
Coexpression of the a2subunit of laminin and the metastatic phenotype | 31 |
Plasminogen activators in fibrinolysis and pericellular proteolysis Studies | 37 |
The effect of ionizing radiation on endothelial cell differentiation | 51 |
An autocrine | 61 |
The biology of vascular endothelial growth factor | 73 |
Scatter factor as a potential tumor angiogenesis factor | 85 |
The metabolic basis of repair | 151 |
Wound healing fibrin and angiogenesis | 161 |
Evidence for their clinical | 173 |
Role of scatter factor in pathogenesis of AIDSrelated Kaposi sarcoma | 181 |
Role of the early response gene cyclooxygenase cox2 in angiogenesis | 191 |
A heparanaseinhibitory bFGFbinding sulfated oligosaccharide that | 199 |
Inhibitors of angiogenesis in human urine | 213 |
How to successfully endothelialize artificial | 229 |
The role of thrombin in angiogenesis | 95 |
The role of thrombospondin in angiogenesis | 105 |
Signal transduction pathways and the regulation of angiogenesis | 115 |
Angiogenesis in the female reproductive organs | 125 |
Angiogenesis in skeletal muscle | 141 |
Other editions - View all
Molecular, Cellular, and Clinical Aspects of Angiogenesis Michael E. Maragoudakis No preview available - 2011 |
Molecular, Cellular, and Clinical Aspects of Angiogenesis Michael E Maragoudakis No preview available - 1996 |
Common terms and phrases
2-methoxyestradiol adhesion angiogenesis angiogenic angiogenic activity angiogenic factors angiogenic response anti-angiogenic antibody assay basement membrane basic fibroblast growth bFGF Biochem biological blood vessels bovine Cancer capillary growth carcinoma cell lines cell proliferation cell types cellular Chem Clinical collagen cornea culture cytokines density differentiation effect endothelial cells endothelial growth factor endothelium enzyme expression extracellular matrix fibrin fibrinolysis fibroblast growth factor Folkman Fotsis function gene genistein hepatocyte growth factor Hudlicka HUVEC increased induced inhibited inhibitor integrin interaction irradiated Klagsbrun Kleinman KS tumor laminin Lelkes macrophages Maragoudakis Matrigel mechanisms mediated metastasis metastatic microvascular migration mitogenic molecular molecules mRNA Natl neovascularization phenotype Physiol plasminogen activator potential production quantitative rabbit radiation receptor Redmer regulation Reynolds role Rosen skeletal muscle stimulation studies synthesis thrombin thrombospondin thymosin thymosin ẞ4 tissue transfected TSP1 tube formation tumor tumor cells tumor growth u-PA vascular endothelial growth VEGF vitro vivo