The Biological Chemistry of Nickel

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Deborah Zamble, Magdalena Rowińska-Żyrek, Henryk Kozlowski
Royal Society of Chemistry, Apr 4, 2017 - Biochemistry - 380 pages

Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects.

This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles).

Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance.

This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

 

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Contents

Introduction to the Biological Chemistry of Nickel
1
Acknowledgements
9
Metallobiology Series No 10
27
Nickel Binding Sites Coordination Modes
43
Chapter 11
56
Urease
60
Crystallographic Analyses of the Active Site Chemistry
98
OneCarbon Chemistry of NickelContaining Carbon
121
Nickel in Microbial Physiology from Single Proteins
237
Acknowledgements
253
Nickel Regulation
259
Structure Function
284
Metallochaperones
296
CrossTalk Between Nickel and Other Metals
306
200
322
220
336

Biochemistry of MethylCoenzyme M Reductase
149
The NiSOD Story
170
Acknowledgements
216
2
223
6
231
Nickel and Virulence in Bacterial Pathogens
339
Application of Ni2+Binding Proteins
357
Subject Index
365
Copyright

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