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abolished actin actin and myosin activity actomyosin actually affinity association balance band beat becomes body bring cell changes charge complex concentration condition contains contractile matter contraction curve decrease depends depolarization developed direct dissociation effect elastic energy essentially evidently excitation expect experiments extracted fact factor favorable fiber folding force formed free energy frequency frog heart function groups heart higher Hill increase indicates influence ionic ions isometric length living material maximal means mechanism membrane molecules motion muscle muscle fiber myosin myosin molecules Nature needed observations opposite particles Physiol picture possible preparation present probably problem produce protein protofibrils psoas quantity reach reaction References relations relaxation rest result salt serum shortening shown shows single solution specific staircase straight stretch structure substances Szent-Györgyi temperature tension threads tion units Weber whole