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abdominal acid adhesions agent ALTEMEIER anastomosis antibiotics bacteria bleeding points blood loss bowel catgut cause cells chest clean wounds clinical closed collagen collagen fibers collagen formation collagen synthesis collagenase colon complications connective tissue contamination Continued cortisone cross-linking debridement dehiscence delayed primary closure drapes dressing Dunphy effect episiotomy epithelial repair factors fascia fibroblast fibroplasia foreign bodies gain in tensile GOULIAN granulation healing wound hemostats hydroxyproline hypovolemia impaired inflammation inflammatory inhibits injury intestinal involved keloids lagen lathyrism layer closure leaks ligated lysis MEDCOM minimal muscle necrosis nonabsorbable sutures normal occur operation oxygen patient peritoneal peritoneum polyglycolic acid postoperative proline protein remove result resutured wound retention sutures SANFORD scar tissue skin graft sterile subcutaneous tissue suppuration surgeon surgical suture material tape technique tendon tensile strength tion trauma ture umbilicus vaginal vascular vitamin C deficiency wound closure wound contraction wound healing wound infection wound repair