Creutzfeldt-Jakob Disease: New ResearchCreutzfeldt-Jakob Disease is a very rare and incurable degenerative neurological disorder that is ultimately fatal. It is the most common of the transmissible spongiform encephalopathies. Transmissible spongiform encephalopathy diseases (also known as prion diseases) are caused by a unique type of infectious agent called prions, an abnormally structured form of a protein found in the brain. Other prion diseases include Gerstmann-Sträussler-Scheinker syndrome (GSS), fatal familial insomnia (FFI) and kuru in humans, as well as bovine spongiform encephalopathy (BSE) and scrapie in animals. This book presents the latest research in this field. |
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Acinetobacter AD/CJD Alzheimer's disease amyloid animals antibodies antigens anxiety apoptosis Armstrong RA Aẞ deposits autoantibodies autoimmune BCL-2 family bovine spongiform encephalopathy brain region BSE infectivity caspase caspase-1 caspase-6 cattle cell death cerebellar cerebral CJD/AD codon coexistence cortical Creutzfeldt Creutzfeldt-Jakob disease vCJD cyclooxygenase dementia deposits in vCJD diagnosis diffuse deposits disease duration disease onset Ebringer exposure factors fCJD Figure florid deposits frequency distributions frontal cortex Gajdusek gene genetic gyrus II/III incubation period inhibit Ironside JW Lancet log-normal model memory impairment molecular months multiple sclerosis myoclonus neurological neurons Neuropathology Neuroscience non-carriers pathogenesis pathology power-law function prion disease prion protein PrP PRNP protein aggregates PrP aggregates PrP deposits PrPsc Prusiner reported sCJD scrapie senile plaques significantly signs size frequency distributions sporadic CJD sporadic Creutzfeldt-Jakob disease stress suggested surface diffusion symptoms tissue transmissible spongiform encephalopathies UK sheep V/VI variant Creutzfeldt-Jakob disease vCJD Zeidler