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Department of Medical Oncology City of Hope National Medical Cen
Superoxide and Oxygen Toxicity
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Academic Press action adriamycin agents alloxan animals antioxidant arachidonic acid assay autoxidation Babior barbiturates Biochem Biol biological Biophys bleomycin blood cancer catalase cellular cheek pouch Chem chemotactic Clin compounds concentration CuSOD CuZnSOD cytotoxic damage Demopoulos doses drugs edema effect electron enzymatic enzyme erythrocytes exogenous superoxide extracellular fatty acids formation free radicals free-radical reactions Fridovich granulocytes human hydrogen peroxide hydroxyl radical increase inflammation inflammatory inhibition injection islets leukocytes levels lipid peroxidation liposomes lung macrophages McCord mechanism membrane metabolism mg/kg mice mitochondria MnSOD molecules neurons neutrophils normal observed oxidation oxygen radicals oxygen toxicity OYANAGUI pathological peroxidase PGG2 PGI2 phagocytes Pharmacol plasma platelet prostaglandin protection protein pulmonary quenching rats reactive reduced release respiratory burst role scavengers singlet oxygen species stimulated streptonigrin studies substrate superox superoxide anion superoxide dismu superoxide dismutase superoxide dismutase activity superoxide radical tion tissue toxicity tumor cells vitro vivo xanthine oxidase