Pathology of OxygenAnne Pomeroy Autor This volume has been designed to provide those interested in oxygen toxicity with a working knowledge of advancement in the field with the intention that the topics described in each chapter will be immediately useful. The book is divided into three general sections. The first and smallest section of the book explains the molecular and biochemical basis of our current understanding of oxygen radical toxicity as well as the means by which normal aerobic cells protect themselves from the toxic effects of oxygen radicals. The second and third sections of about equal length are concerned consecutively with in vivo and in vitro laboratory studies of oxygen toxicity in animals and with the results of clinical studies of patients. |
Contents
CHAPTER | 1 |
Department of Medical Oncology City of Hope National Medical Cen | 2 |
Superoxide and Oxygen Toxicity | 7 |
Copyright | |
49 other sections not shown
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Academic Press action adriamycin agents alloxan animals antioxidant arachidonic acid assay autoxidation Babior barbiturates Biochem Biol biological Biophys bleomycin blood bovine cancer catalase catalyzed cellular cheek pouch Chem chemotactic cis-platinum Clin compounds CuZnSOD cytotoxic damage Demopoulos doses drugs edema effect electron endothelial enzymatic enzyme erythrocytes fatty acids fluid formation free radicals free-radical reactions Fridovich granulocytes H₂O₂ hydrogen peroxide hydroxyl radical inflammation inflammatory inhibition injection leukocytes levels lipid peroxidation liposomes lung macrophages McCord mechanism membrane metabolism mg/kg mice mitochondria MnSOD molecules neurons neutrophils normal O₂ observed oxidation oxygen radicals oxygen toxicity pathological patients peroxidase phagocytes phagocytosis Pharmacol plasma production prostaglandin protection protein pulmonary quenching rats reactive reduced release respiratory burst role scavengers singlet oxygen species stimulated streptonigrin studies substrate superox superoxide anion superoxide dismu superoxide dismutase superoxide dismutase activity superoxide radical tion tissue treatment tumor cells vitro vivo xanthine oxidase