Anesthesia, Volume 1Ronald D. Miller Providing information on anaesthesia, this book contains 17 new chapters covering such topics as barbiturates, neurologic monitoring, regional anaesthesia, clinical care in the hyperbaric environment, acute post-operative pain and teaching anaesthesia. |
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Page 36
... half of the remaining drug was eliminated . The half - life is independent of the amount of drug in the body . Table 2-3 illustrates that five half - lives are required to eliminate 96.9 percent of the administered drug . Elimination half - ...
... half of the remaining drug was eliminated . The half - life is independent of the amount of drug in the body . Table 2-3 illustrates that five half - lives are required to eliminate 96.9 percent of the administered drug . Elimination half - ...
Page 340
... half - life ( 53 minutes ) in infants than adults . 474 Morphine pharmacokinetics are similar in young children ( 1 to 7 years ) , older children ( 7 to 15 years ) , and adults . 795 Koren et al . 863 described no change in t1 / 2a , t1 ...
... half - life ( 53 minutes ) in infants than adults . 474 Morphine pharmacokinetics are similar in young children ( 1 to 7 years ) , older children ( 7 to 15 years ) , and adults . 795 Koren et al . 863 described no change in t1 / 2a , t1 ...
Page 342
... half - life of sufentanil.875 In summary , initial doses of opioids need not be decreased or increased unless CNS ... half - lives . 881,882 Klatz et al.883 showed that meperidine clearance was reduced ( 664 versus 1,316 ml / min ) and ...
... half - life of sufentanil.875 In summary , initial doses of opioids need not be decreased or increased unless CNS ... half - lives . 881,882 Klatz et al.883 showed that meperidine clearance was reduced ( 664 versus 1,316 ml / min ) and ...
Contents
Scope of Modern Anesthetic Practice 1 | 3 |
Introduction to Regional Anesthesia 1369 | 9 |
Basic Principles of Pharmacology and Anesthesia | 27 |
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acid action activity addition administration agents agonist alfentanil alter alveolar alveoli Anesth Analg anesthesia Anesthesiology arterial associated binding block blockade blood flow brain cardiac cardiac output cardiovascular cause changes clinical concentration continuous coronary curve decrease depends depression determined disease distribution dogs dose drug duration effects Eger elimination enflurane et al factors fentanyl function given greater half-life halothane heart hepatic humans important increase induction infusion inhaled anesthetics inhibition intravenous less levels liver lung measured mechanism membrane metabolism mg/kg minutes morphine muscle muscle relaxants myocardial nerve neuromuscular nitrous oxide normal occur opioid oxygen patients percent pharmacokinetics Pharmacol phase plasma position potential present pressure produce propofol protein pulmonary rapid rats receptor reduced relatively release renal resistance respiratory response solubility stimulation studies sufentanil surgery Table thetic thiopental tion tissue usually valve vaporizer vascular ventilation ventricular volume