Cell Cycle Inhibitors in Cancer Therapy: Current StrategiesAntonio Giordano, Kenneth J. Soprano Leading clinicians and investigators review in a comprehensible and user-friendly style all the latest information about the molecular biology of cell cycle control and demonstrate its clinical relevance to understanding neoplastic diseases. Topics range from Cdk inhibitors and cell cycle regulators to the prognostic value of p27 and tumor suppressor genes as diagnostic tools. Actual case studies show how the new molecular understanding has produced such drugs as Flavopiridol and Sulindac. The book brings all the recent critical research findings to bear on clinical practice, and clearly shows their powerful impact on the diagnostics, prognostics, and therapeutics of cancer, AIDS, and cardiovascular disease. |
Other editions - View all
Cell Cycle Inhibitors in Cancer Therapy: Current Strategies Antonio Giordano,Kenneth J. Soprano No preview available - 2010 |
Cell Cycle Inhibitors in Cancer Therapy: Current Strategies Antonio Giordano,Kenneth J. Soprano No preview available - 2003 |
Common terms and phrases
Acad Sci USA alterations apoptosis associated binding Biochem breast cancer Cancer Res carcinogenesis caspases cdk inhibitors CDK2 CDK4 cell cycle cell cycle arrest cell cycle control cell cycle progression cell cycle regulators cell growth cell lines cellular chemopreventive chromosome CKIs clinical complexes cyclin D1 cyclindependent kinase inhibitor degradation differentiation DNA damage domain downregulation effects flavopiridol function G1 arrest G1 phase G1/S phase gene expression Genes Dev genetic genistein growth arrest growth factor inactivation interaction kinase activity leukemia lung cancer lymphoma mammary mechanisms mediated mice modulation Mol Cell Biol molecular mRNA mutations Natl Acad Sci Oncogene Oncol ovarian overexpression of cyclin Pathol pathway patients peptide phosphorylation poor prognosis Proc Natl Acad prostate proteasome protein kinase RA treatment receptor restriction point resveratrol retinoblastoma protein retinoic acid retinoid role senescence signaling specific studies target tissue transcription factors tumor cells tumor suppressor tumorsuppressor genes ubiquitin upregulation