Control of Energy Metabolism

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Britton Chance, Ronald W. Estabrook, John R. Williamson
Academic Press, May 12, 2014 - Science - 454 pages
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Control of Energy Metabolism: A Colloquium of the Johnson Research Foundation focuses on the processes, reactions, and approaches involved in the control of energy metabolism.

The selection first offers information on the respiratory chain as a model for metabolic control in multi-enzyme systems, dynamics and control in cellular reactions, and computer-based analysis of biochemical data. The text then explores purification and properties of rabbit skeletal muscle phosphofructokinase; multiple forms of heart phosphofructokinase; and mechanisms of inhibition and activation of phosphofructokinase in Novikoff ascites tumor cells. Discussions focus on the properties of purified phosphofructokinase; effect of heart extracts on reactivation of phosphofructokinase; active and inactive forms of phosphofructokinase; and effect of hexose phosphate and adenylic nucleotides on reactivation of phosphofructokinase.

The manuscript takes a look at enzyme and metabolite profiles; coordinated stimulation of hexokinase and phosphofructokinase by phosphate in a reconstituted system of glycolysis; control of hexokinase in ascites tumor glycolysis; and cation flux across the mitochondrial membrane as a possible pacemaker of tissue metabolism.

The selection is a vital reference for biochemists and researchers interested in the control of energy metabolism.
 

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Contents

ENZYME CONTENT SUBSTRATE AND COFACTOR AVAILABILITY AND CATION TRANSPORT AS FACTORS IN METABOLIC REGULATI...
107
CONTROL OF METABOLISM IN INTACT TISSUES
281
BICENTENNIAL LECTURES ON CONTROL OF ENERGY METABOLISM
373

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