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abnormal acid ACTA aetiology agenesis AMER anaemia Anat aorta aortic ARCH associated atresia atrial atrial septal defect authors biochemical birth blood bone cardiac caso cause cells child Chir chromosome cleft cleft palate Clin clinical Coll CONGENITAL ANOMALIES CONGENITAL MALFORMATIONS cysts deficiency deformities Dept described diagnosis discussed disease disorder DYSOSTOSIS dysplasia embryonic enzyme erythrocytes excretion favism female fistula foetal gene genetic girl gonadal Graphs 1 Tables haemoglobin heart hereditary Hosp infant Inst intestinal kidney Klin LANCET lesions literature liver male MARFAN'S SYNDROME metabolism mongolism mongoloid mother newborn nius nlus normal observed operation Orthop osteogenesis imperfecta Pathol patients Pediat phenylketonuria pregnancy presented pulmonary artery Radiol radiological renal reported showed stenosis Surg surgical symptoms syndrome Tables 1 Illus teratoma thalassaemia thalidomide thyroid tissue treatment trisomy tumour Turner's syndrome Univ urinary urine ventricular septal defect Wilson's disease