Molecular, Clinical and Environmental Toxicology: Volume 1: Molecular Toxicology

Front Cover
Andreas Luch
Springer Science & Business Media, Apr 3, 2009 - Medical - 470 pages

Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

 

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Contents

Historical milestones and discoveries that shaped the toxicology sciences
1
Physiologically based toxicokinetic models and their application in human exposure and internal dose assessment
37
The role of biotransformation and bioactivation in toxicity
57
damage to DNA and its consequences
87
Role of DNA repair in the protection against genotoxic stress
111
On the impact of the molecule structure in chemical carcinogenesis
151
Chemical induced alterations in p53 signaling
181
Molecular pathways involved in cell death after chemically induced DNA damage
209
Mapping the epigenome impact for toxicology
259
Receptors mediating toxicity and their involvement in endocrine disruption
289
transcription profiling for toxicology assessment
325
The role of toxicoproteomics in assessing organ specific toxicity
367
Highthroughput screening for analysis of in vitro toxicity
401
Glossary
453
Index
461
Copyright

The aryl hydrocarbon receptor at the crossroads of multiple signaling pathways
231

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