Case Studies in Modern Drug Discovery and DevelopmentXianhai Huang, Robert G. Aslanian Learn why some drug discovery and development efforts succeed . . . and others fail Written by international experts in drug discovery and development, this book sets forth carefully researched and analyzed case studies of both successful and failed drug discovery and development efforts, enabling medicinal chemists and pharmaceutical scientists to learn from actual examples. Each case study focuses on a particular drug and therapeutic target, guiding readers through the drug discovery and development process, including drug design rationale, structure-activity relationships, pharmacology, drug metabolism, biology, and clinical studies. Case Studies in Modern Drug Discovery and Development begins with an introductory chapter that puts into perspective the underlying issues facing the pharmaceutical industry and provides insight into future research opportunities. Next, there are fourteen detailed case studies, examining:
Each chapter ends with a list of references leading to the primary literature. There are also plenty of tables and illustrations to help readers fully understand key concepts, processes, and technologies. Improving the success rate of the drug discovery and development process is paramount to the pharmaceutical industry. With this book as their guide, readers can learn from both successful and unsuccessful efforts in order to apply tested and proven science and technologies that increase the probability of success for new drug discovery and development projects. |
Contents
10 | |
AN ANGIOTENSIN II RECEPTOR BLOCKER | 45 |
References | 64 |
References | 85 |
SETTING CHAPTER 5 THE PARADIGM OF TARGETED DRUGS FOR THE TREATMENT | 88 |
References | 100 |
References | 123 |
Acknowledgments | 151 |
DISCOVERY OF ANTIMALARIAL DRUG ARTEMISININ AND BEYOND | 227 |
References | 251 |
DISCOVERY AND PROCESS DEVELOPMENT OF MK4965 A POTENT | 257 |
THE FIRSTAND SECOND | 296 |
References | 330 |
THE FIRSTORALNONPEPTIDE | 336 |
Acknowledgments | 357 |
References | 389 |
References | 188 |
DISCOVERY AND DEVELOPMENT OF MARAVIROC A CCR5 ANTAGONIST | 196 |
Acknowledgments | 217 |
SMALL MOLECULE DRUG DISCOVERY AND DEVELOPMENT | 417 |
ABBREVIATIONS | 432 |
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Case Studies in Modern Drug Discovery and Development Xianhai Huang,Robert G. Aslanian Limited preview - 2012 |