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absorbance absorption acid affinity ammonia Anal analyte antigen applications aqueous assay binding bioluminescence biosensor blood gas buffer calibration cell Chem chemiluminescence chemistry chloroform complex concentration constant covalently detection limit detector determination device dioxide effect electronic emission environmental enzyme excitation fiber optic fiber optic sensors Fiber Sensors fiber-optic fiber-optic biosensor fibre Figure fluorescence intensity fluorescence quenching fluorimetry fluorophore FOCS gases glucose halothane hapten hydrophobic immobilized immunoassay immunosensors indicator instrument interaction interferometer ionophore laser layer light source lipid luminescence material measurement membrane method molecular molecules monitoring monoclonal antibodies monolayer NADH optical fiber optrode oxygen sensor pCO2 pH sensor phase photodiode polymer potential pressure probe Proc protein quenching radiation range reaction reagent receptor refractive index response sample selective sensing sensitivity sensor tip signal solution specific spectral SPIE structure substrate surface techniques temperature sensor titration torr vivo waveguide wavelength Wolfbeis