Signaling Pathways in Liver Diseases
Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.
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Acad Sci USA activation adhesion angiogenesis apoptosis apoptotic beta-catenin binding Biochem Biol Chem Ca2+ cancer caspase cell death cellular ceramide cholangiocytes chronic cirrhosis Clin collagen complex cyclin cytokine domain effects endothelial growth factor enzymes fibrosis function Gastroenterology gene expression hepa hepatectomy hepatic stellate cells hepatocellular carcinoma hepatocytes Hepatology HSEC human increased induced inhibition inhibitor insulin receptor integrin interaction intracellular Kupffer cells levels ligand liver disease liver injury liver regeneration Mallory bodies MAPK mechanism mediated membrane metabolism mice mitochondrial modulate molecular molecules mRNA mutations Natl Acad Sci NF-KB nitric oxide Notch signaling nuclear overexpression p-catenin PDGF phosphorylation Physiol PI3K Proc Natl Acad proliferation proteasome protein kinase rat liver regulation response role signaling pathways Stat3 stimulation studies subunit synthesis target telomere TGF-p tion tissue transcription factors tumor necrosis factor tyrosine kinase upregulation vascular endothelial growth VEGF VEGFR-1 vitro vivo