The Neuron: Cell and Molecular Biology

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Oxford University Press, 2002 - Medical - 603 pages
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The third edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. The first part of the book covers the properties of the many ion channels that shape the way a single neuron generates varied patterns of electrical activity, as well as the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. The second part covers the biochemical pathways that are linked to the action of neurotransmitters and can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory.
 

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Contents

Introduction
3
Signaling in the Brain
5
Form and Function in Cells of the Brain
25
Electrical Properties of Neurons
45
Electrical Signaling in Neurons
47
Membrane Ion Channels and Ion Currents
67
Ion Channels Are Membrane Proteins
89
Ion Channels Membrane Ion Currents and the Action Potential
113
Receptors and Transduction Mechanisms II Indirectly Coupled ReceptorIon Channel Systems
285
Neuromodulation Mechanisms of Induced Changes in the Electrical Behavior of Nerve Cells
315
Sensory Receptors
341
Behavior and Plasticity
373
The Birth and Death of a Neuron
375
Neuronal Growth and Trophic Factors
395
Adhesion Molecules and Axon Pathfinding
435
Formation Maintenance and Plasticity of Chemical Synapses
467

Diversity in the Structure and Function of Ion Channels
139
Intercellular Communication
163
How Neurons Communicate Gap Junctions and Neurosecretion
165
Synaptic Release of Neurotransmitters
195
Neurotransmitters and Neurohormones
223
Receptors and Transduction Mechanisms I Receptors Coupled Directly to Ion Channels
253
Neural Networks and Behavior
507
Learning and Memory
537
Bibliography
571
Index
589
Copyright

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Page 578 - C. Methfessel, M. Mishina, T. Takahashi, T. Takai, M. Kurasaki, K. Fukuda, and S. Numa. (1985) Role of acetylcholine receptor subunits in gating of the channel.
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Page 586 - Hunt SP, Pini A, Evan G 1987 Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 328:632-634 Julius D, Basbaum Al 2001 Molecular mechanisms of nociception.

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About the author (2002)

Irwin B. Levitan is at University of Pennsylvania School of Medicine. Leonard K. Kaczmarek is at Yale University School of Medicine.

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