Reviews in Biochemical Toxicology, Volume 5Ernest Hodgson, John R. Bend, Richard M. Philpot Elsevier North Holland, 1983 - Biochemical toxicology |
Contents
IN VIVO STUDIES | 3 |
Biochemical Mechanisms | 83 |
A PATHWAY FOR | 135 |
Copyright | |
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06-methylguanine A. E. Pegg activity ADR and DNR adriamycin alcohol alkylating agents amine amino anthracyclines arachidonic acid assay Biochem Biol Biophys brain C. S. Lieber Cancer Res carcinogenesis carcinogens cardiac catalase catalyzed cells chelate Chem chemical complex compounds concentrations conjugates cooxidation cytochrome P-450 daunomycin decreased derivatives dose drug effects electron endoperoxide enzymatic enzyme epoxidation ethanol metabolism ethanol oxidation fatty acids formation free radical glutathione Hammarström hepatic hepatocytes human hydrazine hydrogen hydroperoxide hydroxyl increased induced inhibition interaction intercalation isolated hepatocytes kidney leukotriene C4 ligand lipid liver liver microsomes mammalian mechanism membrane metabolites metal ion methyl methyltransferase microsomal molecular mutagenic N-OH-AAF nucleic acids oxygen pathway peroxidase peroxide PGH synthase Pharmacol Proc prostaglandin prostaglandin endoperoxide protein quinone radioligand rat hepatocytes rat liver reaction receptor redox reduced role semiquinone specific structure studies substrate synthesis tion tissue toxicity tumor vitro vivo xenobiotic