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abnormality absence absorption acetazolamide acid agents Aird anticonvulsive antiepileptic therapy associated attacks barbital barbiturates bilaterally bilaterally synchronous biotransformation brain cells cerebral Chapter clinical clonic seizures complex concentration condition cortex cortical develop diazepam diphenylhydantoin discussed disorders dose levels effect of DPH electroencephalographic enzymes epileptic discharge epileptic patients epileptogenic episodes ethosuximide excitatory excretion factors febrile convulsions focal partial focal seizures foci focus forms of epilepsy function genetic half-life increased indicated inhibition inhibitory involved leptic lesions liver manifestations mechanisms membrane mephenytoin mephobarbital metabolism metabolite metharbital motor myoclonic Mysoline neurological neuronal normal occur paramethadione paroxysmal percent phenobarbital phensuximide plasma plasma levels primidone problem psychiatric reported sensory shown side effects slow wave spells stimulation studies subcortical suggested sulthiame Symposium symptoms temporal lobe seizures temporal lobe type therapeutic threshold tion tissue tonic tonic-clonic seizures toxic treatment trimethadione twice per day urine usually wave activity Woodbury zures