Arenaviruses: Biology and Immunotherapy
Springer Berlin Heidelberg, Mar 16, 1987 - Medical - 242 pages
M. B. A. OLDSTONE Viruses are generally studied either because they cause significant human, animal or plant disease or for their utility as materials to probe a basic phenomenon in biology, chemistry, genetics or molecular biology. Arenaviruses are unusually interesting in that they occupy both of these categories. Arenaviruses cause severe human diseases known primarily as the hemor rhagic fevers occurring in South and Latin America (Bolivia: Machupo virus and Argentina: Junin virus) and in Africa (Lassa virus). Because such viruses produce profound disability and may kill the persons they infect, they are a source of economic hardship in the countries where they are prevalent. Further, they provide new problems for health care personnel owing to the narrowing of the world as visitors from many countries increasingly travel to and from these endemic areas. In addition, lymphocytic choriomeningitis virus (LCMV) can infect humans worldwide, although the illness is most often less disabling than those elicited by other arenaviruses. Yet LCMV is likely of greater concern to non-arena-virologists and experimentalists using tissue culture or animals, i. e. , workers in molecular biology, cancer research, virology, immunobiology, etc. , because normal appearing cultured cells or tissues and animals used for research may be persistently infected with LCMV without manifesting clinical disease or cytopathology and transmit that infection to laboratory workers (reviewed OLDSTONE and PETERS 1978). For example, HINMAN et al.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Issues in Pathogenesis
Epidemiology and Control
10 other sections not shown
Other editions - View all
activity acute animals antigen appears arenavirus Argentine associated attenuated blood brain challenge clearance clinical cloned Coto cytotoxic demonstrated detected disease DOHERTY dose effect effector et al evidence experimental expression factor fatal function guinea pigs hemorrhagic fever host human immune Immunol immunological increased induced inhibition inoculation isolated JAHRLING Junin virus Laguens Lassa fever Lassa virus LCMV LCMV infection lethal levels lymphocytic choriomeningitis virus macrophages Maiztegui MARKER mechanism mediated Medicina B Aires meningitis mice monkeys mouse natural neutralizing antibodies NK cells normal observed occur patients persistently infected plasma population present primates production protection reaction recipients replication resistance response restricted ribavirin role sensitive serum showed shown similar specific spleen strain studies suggested T-cell Table tion tissue titers transfer treated treatment viral viremia virus infection virus-specific viruses vitro vivo Weissenbacher MC WELSH