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A-site absorbed absorption acetylate actinomycin active amino acid amino group aminoacyl-tRNA aminoglycosides analogue antibacterial antibiotics antimicrobial bacteria bactericidal benzyl penicillin bile binding body cause cell wall cephalosporins chain chemotherapeutic agents chemotherapy chloramphenicol CO2H coli complex compounds cross-linking CYCLOSERINE cytoplasm D-alanine decrease derivative dihydrofolate dihydropteroic acid doses drug duration of action EF-G enzyme Erythromycin excretion Figure folate folic acid fusidate gastro-intestinal tract given orally Gram-negative Gram-negative bacteria Gram-positive hydrolyse Hypersensitivity reactions infections inhibit inhibitor interaction ionised kidney failure kidney function lipid-solubility liver mechanism of action membrane metabolism metabolites microorganisms mides molecule mRNA mucopeptide mutants nalidixic acid neomycin normal nucleotide occur P-site pABA parenterally pentaglycine pentapeptide peptide bond peptidoglycan Pharmacology phosphonomycin plasma concentrations plasma proteins polypeptide protein synthesis puromycin reduced residue resistant ribosome Rifampicin RNA polymerase secretion Semisynthetic Sensitive Bacteria strains streptomycin subunit sulphamethoxazole sulphanilamide sulphona sulphonamides tetracyclines tion tissues toxic translocation transpeptidase treatment trimethoprim tRNA UDP-NAG undecaprenyl urine vitro