The Ribosome

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CSHL Press, 2002 - Medical - 634 pages
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This is the first book to contain the newly published findings on the structure of the ribosome and discuss their meaning for our understanding of how proteins are made and processed inside the cell. With over 60 contributions from the world's most innovative ribosome biology laboratories, this is the latest volume in the annual series that for over 60 years has provided analysis and interpretation of the most interesting problems in biology.
 

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Contents

Atomic Structures of the 30S Subunit and Its Complexes with Ligands and Antibiotics
17
Progress toward an Understanding of the Structure and Enzymatic Mechanism of the Large
33
Structure of the Ribosome at 5 5A Resolution and Its Interactions with Functional Ligands
57
Do Single Ribosome Molecules Phase Themselves? M van Heel
77
Probing Ribosome Structure and Function by Mutagenesis S T Gregory M A Bayfield
101
Analysis of the Active Site of the Ribosome by Sitedirected Mutagenesis D F Kim K Semrad
119
Features and Functions of the Ribosomal E Site G Blaha and K H Nierhaus
135
The Genetic Code
161
Universal Translation Initiation Factor IF2elF5B T E Dever A RollMecak S K Choi
417
Elongation and Termination
425
Translation Elongation Factor 1 Functions in the Yeast Saccharomyces cerevisiae M Anand
439
Mechanism of Elongation Factor G Function in trNA Translocation on the Ribosome
449
Modulation of Translation Termination Mechanisms by cis and transActing Factors
459
Protein trNA Mimicry in Translation Termination Y Nakamura M Uno T Toyoda
469
Regulation of Protein Synthesis
477
Doublestranded RNAbinding Proteins and the Control of Protein Synthesis and Cell Growth
485

A Postgenomic Perspective C Stathopoulos I Ahel K Ali
175
tRNA Conformity A D Wolfson F J LaRiviere J A Pleiss T Dale H Asahara
185
On Translation by RNAs Alone M Yarus
207
Structure and Function of the Stimulatory RNAs Involved in Programmed Eukaryotic
233
Programmed +1 Translational Frameshifting in the Yeast Saccharomyces cerevisiae Results
249
The Encounter of Cauliflower Mosaic Virus with
269
Initiator MettRNAindependent Translation Mediated by an Internal Ribosome Entry Site
285
The mRNA Capping Apparatus as Drug Target and Guide to Eukaryotic Phylogeny S Shuman
301
A Quality Control Mechanism
321
PUF Proteins and 3UTR Regulation in the Caenorhabditis elegans Germ Line M Wickens
337
Mechanisms of Action and Approaches
353
The Translation of Capped mRNAs Has an Absolute Requirement for the Central Domain
377
Interactions of the Eukaryotic Translation Initiation Factor eIF4E J D Gross H Matsuo M
397
A Multifactor Complex of eIF1 eIF2 eIF3 eIF5 and tRNA Promotes Initiation Complex
403
Translational Regulation in the Cellular Response to Biosynthetic Load on the Endoplasmic
499
A Novel Stressresponse Protein That Binds at the Ribosomal Subunit Interface and Arrests
509
Disassembly of the Posttermination Complex Is Catalyzed
515
The View from
531
The Active 80S RibosomeSec61 Complex R Beckmann C M T Spahn J Frank
543
Ribosome Biogenesis
555
Economics of Ribosome Biosynthesis J R Warner J Vilardell and J H Sohn
567
Role of Small Nucleolar RNA in Maturation of Eukaryotic rRNA
575
Thermodynamics and Kinetics of Central Domain Assembly M I Recht and J R Williamson
591
Nuclear Export of the Large Ribosomal Subunit A W Johnson J H N Ho G Kallstrom
599
The Ribosome in the 21st Century The Poststructural Era P B Moore
607
Author Index
615
Copyright

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Page 335 - Imataka H., Gradi A.. and Sonenberg N. 1998. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. EMBOJ. 17:
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Page 126 - 1980. Sequence of the intron and flanking exons of the mitochondrial 21S rRNA gene of yeast strains having different alleles at the omega and rib-I loci. Cell
Page 387 - Mer-rick WC, and Sonenberg N. 1994a. Dominant negative mutants of mammalian translation initiation factor eIF4A define a critical role for eIF4F in capdependent and cap-independent initiation of translation.
Page 495 - Zhang Y., Zeng H.. Wek R., Schapira M., and Ron D. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. MoL Cell 6:
Page 166 - A.. Mitschler A.. Podjarny A.. Rees B.. Thierry JC. and Moras D. 1991. Class II aminoacyl transfer RNA synthetases: Crystal structure of yeast aspartyl-tRNA synthetase complexed with