Radiobiology in radiotherapy
This book is designed to provide a synthesis of current radiobiological knowledge as it relates to modern radiotherapy practice. An eminent radiobiologist working in a specific area provides the biological background and a clinician then reviews the up-to-date practical implications of this scientific basis. All topical aspects of radiobiology as applied to radiotherapy are covered, including the effects of radiation on cells, normal tissue and tumor, the important features of fractionation, and dose rate. Alternative treatment modalities, such as particle therapy hyperthermia radiation sensitizers and other oxygen modifiers and the interaction with chemotherapeutic agents, are discussed from both the clinical and radiobiological points of view. The contributions stem from the 1987 Royal College of Radiologists' Clinical Oncology symposium.
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Measurement of Human Normal Tissue and Tumour
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acute beam biological bone marrow carcinoma cell cycle cell killing cell lines cervix cGy/min chemotherapy cisplatin Clin cytotoxic Denekamp Dische disease dose fractionation dose Gy dose per fraction dose rate dose-rate drug end-point experimental factors fast neutrons Fowler JF fractionated doses head and neck heat Hodgkin's disease human tumours hyperbaric oxygen hyperfractionation hyperthermia hypoxia hypoxic cells implants increase injury Int J Radiat interstitial isoeffect kidney late effects lesions lethal low-dose-rate lung malignant melanoma metastases misonidazole modality monoclonal antibodies neck cancer neutron therapy normal tissue damage occur Oncol Biol Phys Oncology overall Overgaard particle therapy potential proliferation protons Radiat Biol Radiat Oncol Biol Radiat Res radiation damage radiation dose radiation response radiation therapy radiobiological Radiol radiosensitivity radiotherapy randomized reactions repair Rubin single dose skin techniques temperature therapeutic thermotolerance tolerance total body irradiation total dose toxicity tumour tumour cells tumour control vitro vivo weeks X-rays