Pharmacology of Opioid Peptides
L F Tseong
CRC Press, Sep 1, 1995 - Medical - 500 pages
This book is being published at a time when opioid receptors have recently been cloned. The structural characteristics of opioid receptors and the recent advances in their molecular cloning and expression are explicated. Connecting these cloned opioid receptors with the pharmacology of opioid receptor actions is of particular importance. The use of antisense oligodeoxynucleotides to opioid receptors to elucidate the neural mechanisms of opioid action is detailed.
As analgesia is one of the most important clinical functions for opioids and opioid peptides, this book concentrates on the detailed mechanisms of action of opioids and opioid peptides for the production of analgesia. The significant pharmacologic actions of opioids and opioid peptides in gastrointestinal function, immune function, cardiovascular and respiratory regulation, addiction and the cellular mechanisms involved in tolerance and dependence of opioids are also described.
The book will be of interest both to researchers investigating the neural mechanisms of the pharmacologic and physiologic functions of the endogenous opioid system and to clinicians who are involved in pain management and assessment.
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Selective ligands for u and 6 opioid receptors
k and 8 opioid receptor binding
Molecular characterization of opioid receptors
Enzymes involved in opioid peptide biosynthesis
GProteins and opioid receptors functions
Cellular mechanisms of excitatory and inhibitory actions of opioids
Regulation of enkephalins and catecholamine synthesizing
Functional roles of opioids in the hippocampus
The effects of diabetes on opioidinduced antinociception
Modulation of opioid receptors by antiopioid peptides
Nitrous oxide and endogenous opioid peptides
The role of opioid peptides in environmentallyinduced analgesia
Opioid peptides in gastrointestinal functions
The role of opioid peptides in immune function
Opioid peptides in cardiovascular and respiratory regulation
Endogenous opioids and addiction
a-subunits Academy of Sciences action activity adenylyl cyclase administration adrenal agonists analgesia produced analgesic antagonism antinociception antinociception induced antinociceptive effects astrocytes attenuated B-endorphin binding sites Brain Research cells chronic cross-tolerance D-Ala DAMGO delta opioid receptor diabetic mice dopamine DPDPE drugs dynorphin effects of opioids endogenous opioid enkephalin environmentally-induced analgesia enzyme European Journal Experimental Therapeutics footshock footshock-induced analgesia Fujimoto function G-proteins gene guinea pig Herz hippocampus ic.v immunoreactive increase inhibition inhibitory injection intrathecal Journal of Pharmacology K1 receptor levels Liebeskind LifeSciences ligands mechanisms mediated medulla membrane Met-enkephalin modulation Molecular morphine morphine analgesia mouse mRNA N2O analgesia naloxone naltrexone National Academy neurons Neuroscience nociceptive nonopioid nucleus opiate receptors opioid agonists opioid peptides opioid receptors periaqueductal gray Pharmacology and Experimental Porreca Portoghese potential pretreatment proenkephalin protein rat brain receptor agonists receptor antagonist receptor subtypes regulation release response role selective spinal cord stimulation studies supersensitivity supraspinal tail-flick Takemori Tseng u-opioid vivo Yaksh