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METHODS IN TERATOLOGY
GENETIC ASPECTS OF CONGENITAL DEFECTS
GENESIS OF CONGENITAL DEFECTS
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abortions activity analyzed animals anomalies biology birth cause cells cellular central nervous system Chapter chemical chick embryos chromosomal abnormalities cleft palate clinical congenital defects congenital malformations consequences correlation cortisone Dagg degeneration developmental diabetic differentiation disease disorder dose drugs early ectoderm effect embryogenesis Embryopathic embryos endocrine enzyme epidemiologic estriol etiology example exogenous factors exogenous teratogens experimental experiments fetal fetus fetuses gastrulation gene genetic gestation growth heterozygotes hormones human illustrated in Fig incidence indicated inductive inductor infection inheritance inhibition interaction intrauterine irradiation known lead lesions limb bud maldevelopment mammalian maternal mechanism meclizine ment mesoderm metabolic morphogenesis morphogenetic mother mouse mutant organogenesis percent placenta pregnancy present produced protein radiation retardation role rubella Saxen sensitive period sex chromosome shown specific stages of development strains of mice studies subsequent susceptibility syndrome synthesis teratogenesis teratogenic teratogenic action teratology thalidomide thyroid tion tissue treatment tubules viral virus viruses vitro