Hypothalamic Regulation in Relation to Maladaptive, Obsessive-compulsive, Affiliative, and Satiety Behaviors in Prader-Willi Syndrome

Front Cover
ProQuest, 2007 - 285 pages
0 Reviews
Prader-Willi Syndrome (PWS) is a neurogenetic disorder that occurs in 1 in approximately 20,000 and is the leading cause of genetic obesity. Individuals with PWS present with an array of maladaptive behaviors and compared to others with intellectual disabilities, are more apt to show compulsive behaviors. The features of PWS intuitively suggest hypothalamic and hypothalamic-pituitary-adrenal axis (HPAA) dysfunction. Previous PWS studies have confirmed hypothalamic dysfunction of hormone secretions and hormone-producing neurons, and we address if PWS and the behavioral profile typical of individuals with PWS is associated with alterations in the secretions of oxytocin (OT), vasopressin (VP), and cortisol. OT, VP and cortisol in peripheral plasma were measured using enzyme immunoassay in 21 subjects with PWS (12 females, 9 males) and in 30 normal non-obese control subjects (16 females, 14 males) at a single time point. Behavioral assessments included the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Achenbach Child Behavioral Checklist (CBCL), the Reiss Personality Profiles and a Hyperphagia Questionnaire. Plasma OT (P
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

MOLECULAR GENETICS
11
THE HYPOTHALAMUS AND THE HYPOTHALAMICPITUITARY
23
BEHAVIORS GOVERNED BY THE HYPOTHALAMUS AND
44
VASOPRESSIN
65
THE HYPOTHALAMUS THE HYPOTHALAMICPITUITARY ADRENAL
82
THE HYPOTHALAMUS THE HYPOTHALAMICPITUITARY ADRENAL
95
PREDICTIONS
106
RESULTS
129
DISCUSSION
164
AND AGGRESSION
183
CHAPTER ELEVEN CONCLUSIONS
227
Copyright

Common terms and phrases

Bibliographic information