Basic Science of Oncology, Fifth Edition

Ian F. Tannock, Richard P. Hill, Robert G. Bristow, Lea Harrington

McGraw Hill Professional, Sep 22, 2013 - Medical - 576 pages

NOW IN FULL COLOR!

Discover the science of cancer--with this newly revised, essential introduction to cancer biology and genetics

Here in one well-organized, reader-friendly volume, you'll find everything you must know about the biology underlying cancer and its treatment, supported by the latest peer-reviewed research. Written by preeminent oncology researchers and clinicians, the book highlights the full range of important oncology topics and takes you through the biological basis of current and future biological therapy as well as more traditional approaches to cancer treatment.

Presented in full color, the Fifth Edition of The Basic Science of Oncology is thoroughly updated and refreshed to reflect the latest critical thinking in oncology. For graduate students, oncologists, residents, and fellows, there can be no more useful guide to the bedrock science and practice of oncology than this all-in-one reference.

FEATURES:

• The most current, evidence-based oncology primer--one that encapsulates the science of cancer causation, cancer biology, and cancer therapy
• Key insights into molecular and genetic aspects of cancer familiarize you with cancer biology as applied to prognosis and personalized cancer medicine
• In-depth focus on the discovery, evaluation, and biology of anti-cancer drugs, immunotherapy, and molecularly-targeted agents
• Up-to-date coverage of the basic science of radiation therapy
• Specific chapters/sections on intratumor heterogeneity as it relates to potential new treatment strategies--including tumor microenvironment and metabolism, tumor stem cells, and genomic/proteomic heterogeneity
• NEW! Chapter Essentials synthesize chapter content in a convenient list
• NEW! Color diagrams and schematics summarize important data

Contents

• 1 Introduction to Cancer Biology: 1
• 2 Methods of Molecular Analysis: 5
• 3 Cancer Epidemiology: 51
• 4 Chemical Carcinogenesis: 73
• 5 Genomic Stability and DNA Repair: 89
• 6 Oncogenic Viruses and Tumor Viruses: 117
• 7 Oncogenes and TumorSuppressor Genes: 147
• 8 Cellular Signaling Pathways: 173
• 9 Cell Proliferation and Death: 193
• 10 Tumor Progression and Metastasis: 219
• 11 Angiogenesis: 243
• 12 Tumor Growth Microenvironment and Metabolism: 271
• The Cancer Stem Cell Hypothesis: 295
• 14 Imaging in Oncology: 317
• 15 Molecular and Cellular Basis of Radiotherapy: 333
• 16 Tumor and Normal Tissue Response to Radiotherapy: 357
• 17 Discovery and Evaluation of Anticancer Drugs: 393
• 18 Pharmacology of Anticancer Drugs: 419
• 19 Drug Resistance: 443
• 20 Hormones and Cancer: 469
• 21 The Immune System and Immunotherapy: 501
• 22 Guide to Clinical Studies: 529
• Index: 553

About the author

About the Authors
Ian Tannock, MD, PhD,
Professor of Medical Oncology and Hematology
Princess Margaret Hospital
University of Toronto
Toronto, Ontario, Canada

Richard Hill, PhD
Senior Scientist, Division of Experimental Therapeutics
Professor of Medical Biophysics
University of Toronto
Toronto, Ontario, Canada

Robert Bristow, MD, PhD
Clinician-Scientist, Radiation Medicine Program
Princess Margaret Hospital
University of Toronto
Toronto, Ontario, Canada

Lea Harrington, PhD
Senior Scientist, Division of Cellular and Molecular Biology
University of Toronto
Toronto, Ontario, Canada

Bibliographic information

• Title: Basic Science of Oncology, Fifth Edition; McGraw-Hill international editions
• Authors: Ian F. Tannock, Richard P. Hill, Robert G. Bristow, Lea Harrington
• Edition: 5
• Publisher: McGraw Hill Professional, 2013
• ISBN: 0071813497, 9780071813495
• Length: 576 pages
• Subjects: Medical / Emergency Medicine