Abnormalities of IgG Glycosylation and Immunological Disorders

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D. A. Isenberg, T. W. Rademacher
Wiley, Jul 25, 1996 - Medical - 280 pages
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Glycobiology has become the focus of considerable research in recent years as the role of oligosaccharides in both health and disease has come under scrutiny. During this period particular emphasis has been placed on the glycosylation of human immunoglobulins, notably IgG, not least because clear links with a restricted range of human diseases has been established. Abnormalities of IgG Glycosylation and Immunological Disorders uniquely draws together the facts that have emerged to link abnormalities in IgG glycosylation and immunological disease, especially rheumatoid arthritis. It reviews all aspects of immunoglobulin glycosylation abnormalities, including the structural anatomy of glycoproteins; the methods used to analyse them; the clinical aspects of glycobiology in both human disease and animal models; the glycosylation enzymes and the genes that encode and regulate these enzymes; and the possible pathogenicity of IgG. The chapter authors have been chosen because of the original contributions they have made to this exciting field of research. As such this authoritative and well referenced volume will be indispensable to both clinicians and basic scientists with an interest in glycosylation, as well as rheumatologists, immunologists, bacteriologists and glycobiologists.

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