Bacterial Resistance to Antimicrobials, Second Edition

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Richard G. Wax, Kim Lewis, Abigail A. Salyers, Harry Taber
CRC Press, Dec 5, 2007 - Science - 448 pages
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The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy.

Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem.

Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining -lactam antibiotics with -lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

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A Historical Perspective
Chapter 2 Ecology of Antibiotic Resistance Genes
Chapter 3 Global Response Systems That Confer Resistance
Structure Mechanism and Inhibition
Chapter 5 Mechanisms of Aminoglycoside Antibiotic Resistance
Structure Mechanism and Evolution
Chapter 7 Target Modification as a Mechanism of Antimicrobial Resistance
Chapter 8 Antibiotic Permeability
Chapter 11 Antimicrobial Resistance in the Enterococcus
Chapter 12 Methicillin Resistance in Staphylococcus aureus
Chapter 13 Mechanism of Drug Resistance in Mycobacterium tuberculosis
Chapter 14 Antibiotic Resistance in Enterobacteria
Chapter 15 Resistance as a Worldwide Problem
Chapter 16 Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings
Chapter 17 Antibacterial Drug Discovery in the 21st Century

Chapter 9 Genetic Methods for Detecting Bacterial Resistance Genes
Chapter 10 Evolution and Epidemiology of AntibioticResistant Pneumococci
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