A History of Molecular Biology

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Harvard University Press, 2000 - Science - 336 pages
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Every day it seems the media focus on yet another new development in biology--gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology.

A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries--the double helix, messenger RNA, oncogenes, DNA polymerase--but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg.

This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry.

An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research.

 

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A history of molecular biology

User Review  - Not Available - Book Verdict

Molecular biology is responsible for the recent high-profile developments in cloning, genetic engineering, DNA fingerprinting, etc. Morange, a French molecular biologist, covers the birth of the field ... Read full review

Review: A History Of Molecular Biology

User Review  - Gregory - Goodreads

This book is absolutely fantastic. Morange has the rare ability to describe the state of a scientific field at some point in the past. This requires 'forgetting' one's contemporary view of the field, which is much more difficult than it sounds! Books like this are priceless. Read full review

Contents

Contents Introduction
1
PART I
9
The Roots of the New Science
11
The One GeneOne Enzyme Hypothesis
21
The Chemical Nature of the Gene
30
The Phage Group
40
The Birth of Bacterial Genetics
51
The Crystallization of the Tobacco Mosaic Virus
62
PART II
103
The Discovery of the Double Helix
105
Deciphering the Genetic Code
120
The Discovery of Messenger RNA
139
PART III
165
Genetic Engineering
184
Split Genes and Splicing
204
The Discovery of Oncogenes
219

The Role of the Physicists
67
The Influence of the Rockefeller Foundation
79
A New World View
88
The Role of Physics
99
Molecular Biology in the Life Sciences
243
Notes
259
Acknowledgments
323
Copyright

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About the author (2000)

Michel Morange is Professor of Biology and Director of the Center for the Study of the History of Science at the ecole Normale Superieure, Paris.

Matthew Cobb is in the Faculty of Life Sciences at the University of Manchester, where he lectures on animal behavior. He is also a regular reviewer for the "Times Literary Supplement," and has translated a number of books on popular science and science history.

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