Trends in Atherosclerosis Research
Leon V. Clark
Nova Publishers, 2004 - Medical - 330 pages
Atherosclerosis is a degenerative condition in which arteries build up deposits called plaques (atheromas) which consist of lipids (mainly cholesterol), connective tissue and smooth muscle cells originating from the arterial wall. Plaques develop quietly over a period of years and are unnoticeable until there is an interruption in the normal flow of blood. Plaques may partially or totally block the blood's flow through an artery. Two things that can happen where plaques occur are: bleeding (hemorrhage) into the plaque; and formation of a blood clot (thrombus) on the plaque's surface. Atherosclerosis affects large and medium-sized arteries. The type of artery and where the plaque develops varies with each person. Atherosclerosis research has witnessed startling progress in recent years, partially due to new drugs as well as to new breakthroughs in molecular medicine.
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ABCA1 activation acute adhesion Ann Thorac Surg aorta aortic aprotinin arterial wall artery stiffness associated atheroma atherosclerosis atherosclerotic lesions Biol blood flow brain C-reactive protein CABG CADASIL Cardiol cardiopulmonary bypass cardiovascular disease carotid artery cerebral cerebrovascular cholesterol efflux Circulation Clin clinical cognitive impairment collagen concentration coronary artery bypass coronary artery disease cytokines decreased dysfunction effects endothelial cells enzyme function gene heart heparin human hypertension increased inflammation inflammatory response inhibition inhibitors injury ischemia ischemic L-NMMA lacunar infarctions lacunes large artery stiffness levels lipid lipoprotein macrophages matrix metalloproteinase mechanisms mediators mice molecules myocardial infarction Neurol neutrophil nitric oxide off-pump pathology pathway patients undergoing pattern plasma platelet polymorphism postoperative protein rabbits receptor reduced reperfusion restenosis risk factors role smooth muscle cells statins stroke subcortical syndrome therapy Thorac Cardiovasc Surg tissue transport trial uptake Vasc vascular dementia vessel VSMC Weinberg white matter
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