Drug Discovery Strategies and Methods

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CRC Press, Nov 4, 2003 - Medical - 348 pages
Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.
 

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Contents

1 Protein Crystallography in StructureBased Drug Design
1
2 Src Homology2 Domains and StructureBased SmallMolecule Library Approaches to Drug Discovery
19
3 ThreeDimensional Structure of the Inhibited Catalytic Domain of Human Stromelysin1 by Heteronuclear NMR Spectroscopy
53
Old and New Therapeutic Possibilities
77
5 Development of PET and SPECT Radioligands for Cannabinoid Receptors
111
6 Structural and Pharmacological Aspects of Peptidomimetics
126
7 Linkers and Resins for SolidPhase Synthesis
149
Implications for Drug Action
189
Therapeutic Opportunities
212
10 Uncoating and Adsorption Inhibitors of Rhinovirus Replication
239
11 Profiles of Prototype Antiviral Agents Interfering with the Initial Stages of HIV Infection
269
Index
293
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