Holland-Frei Cancer Medicine 8

Front Cover
PMPH-USA, 2010 - Medical - 2021 pages
The consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists and others who treat cancer patients, Cancer Medicine 8 covers the ever-widening sphere of current cancer knowledge and clinical practice.

In this new 8th edition an outstanding editorial team from world-renowned medical centers continues to hone the leading edge forged in previous editions, with timely information on biology, immunology, etiology, epidemiology, prevention, screening, pathology, imaging and therapy.

The book is a testament to the editorial panel's creed that innovative, comprehensive, multidisciplinary treatment of cancer patients must be grounded in a fundamental understanding of cancer biology. Cancer Medicine 8 does a superb job of bringing scientific principles into clinical practice. This text is the ultimate resource of new information providing the basis for better informed cancer therapy choices.

Cancer Medicine 8 features hundreds of 4-color illustrations, photographs, tables, graphs and algorithms that make this text an invaluable clinical tool in recognizing characteristic appearances of both patient and tissue.

The 137 tightly focused chapters are organized into 5 sections:

I: Cardinal Manifestations of Cancer
II: Scientific Foundations of Cancer
III: Principles of Cancer Diagnosis
IV: Principles of Therapeutic Modalities
V: Principles of Multidisciplinary Management

Major Revisions:

Chapter 6: Oncogenes An entire section is devoted to oncogenes like kit, Ret, Braf, Akt genes and the new drugs that specifically target them. This chapter not only provides a list of these new therapies but also insight as to how they target the oncogenes and their mutations, as well as therapy response and efficacy.
Chapter 11: Tumor Angiogenesis This chapter provides a wealth of new data and understanding of the mechanisms of angiogenesis and how it contributes to the malignancy of various cancers The Clinical Advancement section provides an extensive summary of new trials investigating numerous novel angiogenesis agents
Chapter 33: Chemoprevention This chapter also provides a considerable amount of new information for a broad range of clinical trials such as the HPV vaccine trial Future, Select, Star, Approve and PreSAP. The rationales for these trials are discussed and resulting data from the completed trials are presented.
Chapter 55: Cytokines Research on cytokines is another area that is exploding in magnitude. This chapter presents a wealth of new information on promising new therapeutic agents.There is also updated information on the therapeutic usage of currently available agents such as hemotopoietic growth factors (HGF), erythropoietin and thromobopoietic agents.
Chapter 56: Monoclonal Serotherapy A considerable amount of research has been done in the past few years on therapeutic and targeted agents in cancer therapy. Updated information and data is provided from recent trials for therapies previously discussed in Cancer Medicine edition 7 covering therapeutic agents and targeted toxins.
Chapter 77: Neoplasms of the Head and Neck There is a discussion of changes in treatment methods for certain cancers such as the recent shift from surgery to combined chemotherapy with radiotherapy for tonsillar cancer, nasal and paranasal sinuses cancers and laryngeal cancer.
Chapter 78: Lung Cancer Advances in diagnostic techniques are described such as ultrasound-guided fine needle aspiration or electromagnetic navigation diagnostic bronchoscopy. Video assisted thoracoscopic surgery (VATS) discussion is updated. New sections are devoted to prognostic and predictive biomarkers.

 

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Contents

I
1
III
5
V
26
VI
40
VII
51
VIII
68
IX
86
X
102
XCI
899
XCIII
904
XCV
915
XCVI
923
XCVII
933
XCVIII
940
XCIX
959
CI
999

XI
125
XII
141
XIII
149
XIV
170
XV
175
XVI
190
XVII
225
XVIII
237
XIX
248
XX
262
XXI
270
XXII
279
XXIII
291
XXV
298
XXVI
302
XXVII
311
XXVIII
318
XXIX
335
XXXI
347
XXXIII
359
XXXIV
364
XXXV
371
XXXVI
386
XXXVII
398
XXXIX
411
XL
419
XLI
446
XLIII
464
XLV
473
XLVI
489
XLVIII
490
XLIX
499
L
510
LII
528
LIV
541
LVI
550
LVII
558
LVIII
568
LIX
587
LX
597
LXI
611
LXIII
621
LXV
633
LXVI
645
LXVIII
655
LXX
679
LXXII
686
LXXIII
710
LXXIV
725
LXXV
737
LXXVI
750
LXXVII
759
LXXVIII
776
LXXIX
793
LXXX
810
LXXXI
823
LXXXIII
830
LXXXIV
838
LXXXV
846
LXXXVII
854
LXXXVIII
863
LXXXIX
881
CIII
1044
CV
1053
CVI
1062
CVII
1067
CVIII
1074
CIX
1086
CX
1109
CXII
1124
CXIII
1132
CXV
1144
CXVII
1172
CXVIII
1194
CXX
1204
CXXI
1212
CXXII
1219
CXXIV
1228
CXXV
1255
CXXVI
1263
CXXVII
1289
CXXVIII
1299
CXXX
1325
CXXXII
1338
CXXXIII
1344
CXXXIV
1376
CXXXV
1384
CXXXVI
1393
CXXXVIII
1459
CXXXIX
1487
CXL
1497
CXLII
1517
CXLIII
1544
CXLIV
1559
CXLV
1582
CXLVII
1591
CXLVIII
1604
CXLIX
1622
CLI
1645
CLII
1659
CLIV
1668
CLVI
1686
CLVII
1696
CLIX
1713
CLXI
1723
CLXIII
1740
CLXV
1757
CLXVII
1763
CLXVIII
1779
CLXIX
1788
CLXX
1797
CLXXI
1813
CLXXII
1823
CLXXIII
1832
CLXXIV
1849
CLXXV
1871
CLXXVI
1880
CLXXVIII
1891
CLXXIX
1901
CLXXXI
1915
CLXXXII
1921
CLXXXIII
1941
CLXXXV
1961
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About the author (2010)

Waun Ki Hong, MD Division Head Thoracic Head & Neck Medical Oncology, MD Anderson Cancer Center

Donald W. Kufe, MDProfessor of MedicineDana Farber Cancer InstituteHarvard Medical School

Robert C. Bast Jr, MDVice President for Translation ResearchMD Anderson Cancer Center

William Hait, MD, PhDSenior VP and Worldwide Head Ortho Biotech Oncology Research & Development (ORD), Johnson & Johnson Pharmceutical Research & Development

Raphael E. Pollock, MD, PhDHead of the Division of Surgery, Professor and Chairman of the Department of Surgical Oncology, Senator A. M. Aiken, Jr. Distinguished Chair M. D. Anderson Cancer Center

Ralph R. Weichselbaum, MDDaniel K. Ludwig ProfessorChair Dept of Radiology and Cellular OncologyUniversity of Chicago HospitalDirector Chicago Tumor Institute

James F. Holland, MD, ScD (hc)Director Emeritus, Derald H. Ruttenberg Cancer CenterMount Sinai School of Medicine

Emil Frei, III, MDPhysician in Chief EmeritusDana Farber Cancer Institute

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