Systems Biology: Philosophical FoundationsFred Boogerd, Frank J. Bruggeman, Jan-Hendrik S. Hofmeyr, H.V. Westerhoff Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies. * Answers the question of what distinguishes the living from the non-living* An in-depth look to a vigorous and expanding discipline, from molecule to system* Explores the region between individual components and the system |
Contents
| 21 | |
SECTION III Theory and models | 121 |
SECTION IV Organization in biological systems | 215 |
SECTION V Conclusion | 319 |
Common terms and phrases
acid action potential approach autonomous systems behavior biochemical biochemistry biological systems biologists Boogerd bottom-up Bruggeman Cambridge causal cell biology cellular chemical chemistry coli complex systems components concentrations concept context cycle dynamics emergence environment enzyme equations evolution evolutionary example experimental fabrication feedback flux function Gánti genes genetic genomics glucose Hofmeyr hypotheses important interactions Journal kinetic Kitano lac operon living cell living organisms living systems mathematical mechanism mechanistic explanation membrane metabolic control analysis metabolic pathways metabolites Metabolomics methodology methods modules molecular biology molecules Moreno natural nonlinear omic Palsson parameter pathway modeling phenomena philosophy of biology Philosophy of Science physics Physiology principles processes properties proteins quantitative reactions reduction reductionism reductionist regulatory robust role Rosen Ruiz-Mirazo scientific selection self-fabricating self-organization sequence simulation specific strategy structure synthesis systems biology systeome theoretical theory thermodynamics top-down understanding University Press Westerhoff HV Wimsatt