Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids

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Cambridge University Press, Apr 23, 1998 - Science - 356 pages
9 Reviews
Probablistic models are becoming increasingly important in analyzing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analyzing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it is accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time presents the state of the art in this new and important field.

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LibraryThing Review

User Review  - amarcobio - LibraryThing

One of the best books in bioinformatics ever published. It focus on probability models, which may seem quite narrow, but actually it covers the most important aspect in bioinfromatics: sequence comparison. Every bioinformatician should keep (and read) a copy. Read full review

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