Diabetes: Clinical Science in Practice

R. D. G. Leslie, David C. Robbins

Cambridge University Press, Mar 9, 1995 - Medical - 492 pages

This significant new publication provides a summary and overview of the most recent scientific advances in diabetes research, and highlights the role of these developments in advancing clinical practice. Diabetes is one of the major causes of morbidity and mortality in the developed world, and its prevalence elsewhere is on the increase. It affects in excess of 100 million people worldwide. Recent scientific advances have clarified our understanding of the causes and consequences of this devastating disease. These scientific developments are playing an increasingly important role in clinical practice and could well lead the way to the prevention of complications and even a cure for the disease. An international and authoritative team of authors draws together this knowledge and the most recent developments to provide an up to date account which will benefit researchers and clinicians.

Contents

• The regulation of insulin gene transcription: 15
• Molecular structure of insulin: 32
• Insulin receptors: 48
• The role of protein phosphorylation in insulin action: 61
• Glucose transport mechanisms: 77
• Glucose homeostasis: 96
• Genetics of insulindependent diabetes: 117
• Aetiology of insulindependent diabetes: 134
• Epidemiology of noninsulindependent diabetes: 157
• Islet amyloid polypeptide and amyloid in the islets: 189
• a risk syndrome: 200
• Epidemiology of the complications of diabetes: 221
• Diabetic neuropathy: 237
• Diabetic foot infections: 250
• Ocular complications of diabetes: 256
• Diabetic nephropathy: 264
• The personal social and economic burden of diabetic: 272
• Mortality among persons with diabetes: 279
• Glycation and diabetic complications: 288
• The sorbitol pathway and diabetic complications: 313
• Proteinuria and diabetic complications: 331
• Pharmacological approaches to noninsulindependent: 353
• Insulin and insulin analogues: 360
• Hypoglycaemia: 375
• Strategies for prevention of insulindependent diabetes: 392
• Treatment of early diabetic renal disease with special: 405
• Pancreatic transplantation in humans with diabetes mellitus: 425
• Rational insulin management of insulindependent diabetes: 434
• Rationale in the management of noninsulindependent: 450
• Psychosocial aspects of diabetes care: 465
• Index: 478

Bibliographic information

• Title: Diabetes: Clinical Science in Practice
• Editors: R. D. G. Leslie, David C. Robbins
• Edition: illustrated
• Publisher: Cambridge University Press, 1995
• ISBN: 0521450292, 9780521450294
• Length: 492 pages
• Subjects: Medical / Endocrinology & Metabolism