Vogel and Motulsky's Human Genetics: Problems and ApproachesThe fourth, completely revised edition of this classical reference and textbook presents a cohesive and up-to-date exposition of the concepts, results, and problems underlying theory and practice in human and medical genetics. In the 10 years since the appearance of the third edition, many new insights have emerged for understanding the genetic basis of development and function in human health and disease. Human genetics, with its emphasis on molecular concepts and techniques, has become a key discipline in medicine and the biomedical sciences. The fourth edition has been extensively expanded by new chapters on hot topics such as epigenetics, pharmacogenetics, gene therapy, cloning and genetic epidemiology. In addition a section giving an overview on the main model organisms (mouse, canine, dog, worm, fly, yeast) used in human genetics research has been introduced. This book will be of interest to human and medical geneticists, scientists in all biomedical sciences, physicians and epidemiologists, as well as to graduate and postgraduate students who desire to learn the fundamentals of this fascinating field. |
Contents
1 | 11 |
1 | 17 |
1 | 25 |
2 | 44 |
Conclusions | 79 |
Modes of Inheritance | 129 |
2 | 145 |
Conclusions | 160 |
Description and Dynamics | 495 |
13 | 501 |
14 | 540 |
Conclusions | 545 |
Conclusions | 580 |
Comparison of Satellite DNA in Higher Primates | 593 |
Conclusions | 618 |
15 | 623 |
References | 246 |
Conclusions | 251 |
Genetic Diseases | 257 |
Is Found Among Homozygotes In Almost All Enzyme Defects Clinical Findings | 268 |
3 | 299 |
4 | 325 |
5 | 334 |
Developmental Genetics | 361 |
Conclusions | 380 |
10 | 386 |
Conclusions | 426 |
Neoplasias with Constant Chromosomal Aberrations | 440 |
Conclusions | 454 |
12 | 458 |
Characteristics in Irradiated Human Populations Survivors of Atomic Bombs | 475 |
Conclusions | 490 |
Conclusions | 683 |
Affective Disorders and Schizophrenia | 693 |
17 | 694 |
Conclusions | 703 |
18 | 706 |
Conclusions | 710 |
Conclusions | 730 |
Genetic Manipulations and the Biological Future | 733 |
Methods for Estimating Gene Frequencies | 749 |
Data Bases and Expert Systems | 757 |
Heritability Estimates from Twin Data | 769 |
Genetic Counseling | 775 |
Programs and Examples | 783 |
| 793 | |
| 807 | |
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Common terms and phrases
aabb abnormal activity affected alleles amino acid analysis anemia anomalies antigen autosomal behavior biochemical blood group cancer caused centromere chain chro chromatin chromo clinical codon common consanguineous cytogenetic deficiency deletions disease distribution dominant DZ twins enzyme enzyme defects estimate evolution example factor VIII factors families female function G6PD gene frequencies genome genotype germ cells globin haplotypes hemoglobin hemophilia hereditary heterozygotes heterozygous homozygotes homozygous Hum Genet human genetics hypothesis increase individuals lead linkage loci locus male markers maternal age mating mechanisms meiosis metabolic methods mode of inheritance molecular mosome mouse muta mutagenic mutation rate netic nondisjunction normal observed occur pairs parents patients phenotype polymorphisms protein radiation receptor recessive relatively risk Sect selection sickle cell somatic specific structure studies syndrome Table thalassemia tion traits translocation trisomy tumor variability variants various X chromosome X-linked zygote